IER2 Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) IER2 Polyclonal antibody
Uniprot No.：

Q9BTL4
基因名：

IER2
别名：

IER2 antibody; ETR101 antibody; PIP92 antibody; Immediate early response gene 2 protein antibody; Protein ETR101 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Immediate early response gene 2 protein (1-223AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

DNA-binding protein that seems to act as a transcription factor. Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells. May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo. Promotes cell motility, seems to stimulate tumor metastasis.
基因功能参考文献：
1. IER2 promoted hepatocellular carcinoma cell adhesion and motility by directly increasing ITGB1 expression and subsequently activating the ITGB1FAKSrcpaxillin signal pathway. PMID: 27840969
2. results from western blot analysis showed that the activity of the focal adhesion kinase (FAK) can be regulated by IER2. PMID: 26260137
3. ectopic Ier2 expression promoted the motility and invasiveness of poorly metastatic 1AS pancreatic tumor cells in vitro PMID: 22120713
4. the functioning of ETR101 as a transcriptional activator for the gene ISYNA1 PMID: 19584537
亚细胞定位：

Cytoplasm. Nucleus.
蛋白家族：

IER family
组织特异性：

Expressed in activated T-cells (at protein level). Expression increases in metastatic tumor cells (at protein level).
数据库链接：

HGNC: 28871

KEGG: hsa:9592

STRING: 9606.ENSP00000292433

UniGene: Hs.501629