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  4. HECW2 Antibody, HRP conjugated

HECW2 Antibody, HRP conjugated

说明书
  • 中文名称：
    HECW2兔多克隆抗体, HRP偶联
  • 货号：
    CSB-PA889188LB01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HECW2 Polyclonal antibody
  • Uniprot No.：
    Q9P2P5
  • 基因名：
    HECW2
  • 别名：
    C2 and WW domain-containing protein 2 antibody; E3 ubiquitin protein ligase HECW2 antibody; E3 ubiquitin-protein ligase HECW2 antibody; HECT antibody; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 antibody; Hecw2 antibody; HECW2_HUMAN antibody; KIAA130 antibody; KIAA1301 antibody; NEDD4 like E3 ubiquitin protein ligase 2 antibody; NEDD4 Related E3 Ubiquitin Ligase antibody; NEDD4-like E3 ubiquitin-protein ligase 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase HECW2 protein (495-641AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    HRP
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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HECW2 antibodies

HECW2 Proteins

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition.
  • 基因功能参考文献：
    1. Results show that HECW2 interacts with two lamin A-binding proteins: proliferating cell nuclear antigen (PCNA), via a canonical PCNA-interacting protein (PIP) motif, and lamin B1. HECW2 mediates their ubiquitination and targets them for proteasomal degradation. PMID: 29753763
    2. HECW2, a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT-like 1 (AMOTL1) stability. PMID: 27498087
    3. HECW2 is an ubiquitin ligase that stabilises p73, a crucial mediator of neurodevelopment and neurogenesis. This study implicates pathogenic genetic variants in HECW2 as potential causes of neurodevelopmental disorders in humans. PMID: 27389779
    4. This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified. PMID: 27334371
    5. Low HECW2 expression is associated with cervical cancer. PMID: 25156441
    6. NEDL2 is a novel substrate of APC/C-Cdh1 as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition PMID: 24163370

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  • 相关疾病：
    Neurodevelopmental disorder with hypotonia, seizures, and absent language (NDHSAL)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, spindle.
  • 组织特异性：
    Predominantly expressed in adult brain, lung and heart.
  • 数据库链接：

    HGNC: 29853

    OMIM: 617245

    KEGG: hsa:57520

    STRING: 9606.ENSP00000260983

    UniGene: Hs.633212

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