HECW1 Antibody

中文名称：

HECW1兔多克隆抗体
货号：

CSB-PA748484HA01HU
规格：

￥440
图片：
Immunofluorescence staining of A549 cells with CSB-PA748484HA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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产品名称：

Rabbit anti-Homo sapiens (Human) HECW1 Polyclonal antibody
Uniprot No.：

Q76N89
基因名：

HECW1
别名：

C2 and WW domain-containing protein 1 antibody; E3 ubiquitin-protein ligase HECW1 antibody; HECT antibody; HECT type E3 ubiquitin ligase antibody; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 antibody; HECT, C2 and WW domain-containing protein 1 antibody; HECW 1 antibody; Hecw1 antibody; HECW1_HUMAN antibody; hNEDL1 antibody; NEDD4 like ubiquitin protein ligase 1 antibody; NEDD4-like E3 ubiquitin-protein ligase 1 antibody; NEDL1 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase HECW1 protein (751-900AA)
免疫原种属：

Homo sapiens (Human)

标记方式：

Non-conjugated

本页面中的产品，HECW1 Antibody (CSB-PA748484HA01HU)，的标记方式是Non-conjugated。对于HECW1 Antibody，我们还提供其他标记。见下表：

标记方式	货号	产品名称	应用
HRP	CSB-PA748484HB01HU	HECW1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA748484HC01HU	HECW1 Antibody, FITC conjugated
Biotin	CSB-PA748484HD01HU	HECW1 Antibody, Biotin conjugated	ELISA

克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Antigen Affinity purified & Affinity purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA, IF
推荐稀释比：

Application Recommended Dilution

IF 1:50-1:200
Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
基因功能参考文献：
1. Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly. PMID: 26880200
2. Ndel1 regulates Dyn2 GTPase activity and impacts GluR1-containing membranes distribution in a manner reminiscent of Dyn2. PMID: 21283621
3. These findings suggest that the human NEDL1 transgenic mice might develop Amyotrophic lateral sclerosis-like symptoms, showing signs of motor abnormalities, accompanied with significant reduction in muscle strength. PMID: 20976258
4. These findings suggest that RNF43 is associated with p53-mediated apoptosis in collaboration with NEDL1 in colorectal carcinogenesis. PMID: 21108931
5. interaction among misfolded SOD1, NEDL1, translocon-associated protein-delta, and Dishevelled-1 forms a ubiquitinated protein complex that is included in potentially cytotoxic protein aggregates PMID: 14684739
6. functional interaction of NEDL1 with p53 might contribute to the induction of apoptosis in cancerous cells bearing wild-type p53. PMID: 18223681
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亚细胞定位：

Cytoplasm.
组织特异性：

Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
数据库链接：

HGNC: 22195

OMIM: 610384

KEGG: hsa:23072

STRING: 9606.ENSP00000379228

UniGene: Hs.164453

HECW1 Antibody

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