Gfer Antibody, FITC conjugated

^{Rare Species}

中文名称：

Gfer兔多克隆抗体, FITC偶联
货号：

CSB-PA733907HC01RA
规格：

￥880
其他：

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产品名称：

Rabbit anti-Rattus norvegicus (Rat) Gfer Polyclonal antibody
Uniprot No.：

Q63042
基因名：

Gfer
别名：

Gfer antibody; AlrFAD-linked sulfhydryl oxidase ALR antibody; EC 1.8.3.2 antibody; Augmenter of liver regeneration antibody
宿主：

Rabbit
反应种属：

Rat
免疫原：

Recombinant Rat FAD-linked sulfhydryl oxidase ALR protein (1-198AA)
免疫原种属：

Rattus norvegicus (Rat)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. May have a function in liver regeneration and spermatogenesis.
基因功能参考文献：
1. our results demonstrate that Growth Factor Erv1-Like gene knock-down, i.e., the lack of Augmenter of Liver Regeneration, modifies the expression of genes involved in cell apoptosis and inhibits early phase of DNA synthesis. PMID: 24880092
2. improves hepatocyte survival and promoted liver recovery after transplantation for acute liver failure PMID: 23337881
3. ALR may serve as a potential diagnostic marker of hepatocellular stress and/or acute inflammatory conditions. PMID: 23073658
4. ALR level in serum may indicate hepatocyte proliferation or liver regeneration. High ALR level in serum in early stage of acute-on-chrinic liver failure may mean a good prognosis. PMID: 22246190
5. Loss of augmenter of liver regeneration is associated with renal dysfunction in ischaemia/reperfusion injury. PMID: 20332418
6. effectively accelerates kidney recovery after acute renal failure induced by gentamicin; the protective effect is associated with enhanced proliferation of renal tubular cells PMID: 20030531
7. crystal structure of ALR has been determined to 1.8 A, and possible physiological roles of ALR are examined PMID: 12717032
8. Data show that augmenter of liver regeneration factor (ALR) can promote hepatocyte proliferation induced by Kupffer cells, suggesting that Kupffer cells play a dual role in liver regeneration. PMID: 16937468
9. review of the molecular biology of ALR [review] PMID: 16937489
10. Demonstrate that Alrp improves SH-SY5Y cells survival in H(2)O(2)-induced apoptosis. PMID: 19629817
11. Demonstrate specific G-protein coupled binding of ALR and its function in Kupffer cells and suggest that mediators produced by ALR-stimulated Kupffer cells may elicit physiologically important effects on hepatocytes. PMID: 19859909
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亚细胞定位：

Mitochondrion intermembrane space. Mitochondrion.
数据库链接：

KEGG: rno:27100

STRING: 10116.ENSRNOP00000017917

UniGene: Rn.11039

Gfer Antibody, FITC conjugated

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