GRAMD4 Antibody, Biotin conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) GRAMD4 Polyclonal antibody
Uniprot No.：

Q6IC98
基因名：

GRAMD4
别名：

GRAMD4; DIP; KIAA0767; GRAM domain-containing protein 4; Death-inducing protein
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human GRAM domain-containing protein 4 protein (23-161AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

Biotin
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response.
基因功能参考文献：
1. The expression of GRAMD4 is up-regulated in hepatocellular carcinoma cell(HCC cell) lines and HCC tissues, and the increased expression is correlated with the clinicopathological characteristics of HCC. PMID: 23388340
2. GRAMD4 induces changes in Bcl-2 and Bax protein levels PMID: 21127500
3. localizes to the mitochondria, upregulated following E2F1 induction PMID: 15565177
4. DIP induces p53-independent caspase-dependent and -independent apoptosis. DIP is localized in the mitochondria. DIP accumulates upon E2F1 activation. PMID: 15565177
亚细胞定位：

Mitochondrion membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
组织特异性：

Expressed in lung and in primary lung squamous cell carcinoma (LSCC).
数据库链接：

HGNC: 29113

OMIM: 613691

KEGG: hsa:23151

STRING: 9606.ENSP00000354313

UniGene: Hs.475150