GID8 Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) GID8 Polyclonal antibody
Uniprot No.：

Q9NWU2
基因名：

GID8
别名：

GID8 antibody; C20orf11 antibody; TWA1Glucose-induced degradation protein 8 homolog antibody; Two hybrid-associated protein 1 with RanBPM antibody; Twa1 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Glucose-induced degradation protein 8 homolog protein (1-228AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation.
基因功能参考文献：
1. The results identify Twa1 as a previously undescribed regulator of the Wnt pathway for promoting colorectal tumorigenesis by facilitating beta-catenin nuclear retention. PMID: 28829046
亚细胞定位：

Cytoplasm. Nucleus.
蛋白家族：

GID8 family
组织特异性：

Up-regulated in colorectal cancer tissues (at protein level).
数据库链接：

HGNC: 15857

OMIM: 611625

KEGG: hsa:54994

STRING: 9606.ENSP00000266069

UniGene: Hs.353013