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  4. GCHFR Antibody, Biotin conjugated

GCHFR Antibody, Biotin conjugated

说明书
  • 中文名称：
    GCHFR兔多克隆抗体, Biotin偶联
  • 货号：
    CSB-PA009318LD01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GCHFR Polyclonal antibody
  • Uniprot No.：
    P30047
  • 基因名：
    GCHFR
  • 别名：
    GCHFR antibody; GFRP antibody; GFRP_HUMAN antibody; GTP cyclohydrolase 1 feedback regulatory protein antibody; GTP cyclohydrolase I feedback regulator antibody; GTP cyclohydrolase I feedback regulatory protein antibody; HsT16933 antibody; MGC138467 antibody; MGC138469 antibody; p35 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human GTP cyclohydrolase 1 feedback regulatory protein (11-55AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Biotin
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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GCHFR antibodies

GCHFR Proteins

靶点详情

  • 功能：
    Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
  • 基因功能参考文献：
    1. homozygous individuals for the TT haplotype were less likely to respond to the SSRI fluoxetine than to the nortriptyline suggesting a biological process through which GCHFR promoter variants might influence antidepressant response. PMID: 20351752
    2. Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein PMID: 11799107
    3. allosteric regulation of GTPCH-I activity in the cardiovascular system maybe an important mechanism regulating BH4 levels through GTPCH-I feedback regulatory protein signaling PMID: 15649650
    4. GFRP/GTPCHI axis functions in epidermal keratinocytes and melanocytes in the cytosol and nucleus. PMID: 16778797
    5. GCH1 mutations in Japanese patients with DYT5 dystonia. In some of them, the GCH1 enzyme activity was proved to be impaired. PMID: 17101830
    6. The co-expression of GTP cyclohydrolase I (GCHI) with tyrosine hydroxylase (TH) indicates that TH is indeed active in human neurosecretory neurons. PMID: 17135716
    7. Demonstrate role for GFRP in regulating iNOS-mediated NO synthesis and suggest that the allosteric regulation of GTP-CH1 activity by GFRP may be an important mechanism regulating BH(4) and NO levels in vivo. PMID: 18372436
    8. crystal structure PMID: 11580249

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  • 亚细胞定位：
    Nucleus. Nucleus membrane. Cytoplasm, cytosol.
  • 蛋白家族：
    GFRP family
  • 组织特异性：
    In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).
  • 数据库链接：

    HGNC: 4194

    OMIM: 602437

    KEGG: hsa:2644

    STRING: 9606.ENSP00000260447

    UniGene: Hs.631717

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