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中文名称：
GBA3兔多克隆抗体
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货号：
CSB-PA009291GA01HU
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规格：
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其他：
产品详情
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Uniprot No.：
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基因名：
GBA3
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别名：
CBG antibody; CBGL1 antibody; Cytosolic beta glucosidase antibody; Cytosolic beta glucosidase like protein 1 antibody; Cytosolic beta-glucosidase antibody; Cytosolic beta-glucosidase-like protein 1 antibody; GBA3 antibody; GBA3_HUMAN antibody; GLUC antibody; Glucosidase beta acid 3 antibody; Klotho related protein antibody; KLRP antibody
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宿主：
Rabbit
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反应种属：
Human
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免疫原：
Human GBA3
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免疫原种属：
Homo sapiens (Human)
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抗体亚型：
IgG
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纯化方式：
Antigen Affinity purified
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浓度：
It differs from different batches. Please contact us to confirm it.
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保存缓冲液：
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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产品提供形式：
Liquid
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应用范围：
ELISA,WB
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Protocols：
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储存条件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶点详情
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功能：
Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics. Could also play a role in the catabolism of cytosolic sialyl free N-glycans.
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基因功能参考文献：
- cytosolic GBA3 is likely involved in the catabolism of cytosolic sialyl free N-glycans, possibly by stabilizing the activity of the NEU2 protein PMID: 26193330
- No correlation was observed between GBA3 1368A/T haplotypes and severity of type 1 Gaucher disease manifestation PMID: 20728381
- The positioning of a substrate molecule (quercetin-4'-glucoside) by homology modelling revealed that hydrophobic interactions dominate the binding of the aglycone moiety. PMID: 17555766
- The crystal structure of a covalent intermediate of the KLrP mutant E165Q, in which glucose was covalently bound to a nucleophile, Glu(373), is reported. PMID: 18662675
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亚细胞定位：
Cytoplasm, cytosol.
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蛋白家族：
Glycosyl hydrolase 1 family, Klotho subfamily
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组织特异性：
Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas.
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数据库链接：
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