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GALR3 Antibody

  • 中文名称:
    GALR3兔多克隆抗体
  • 货号:
    CSB-PA070050
  • 规格:
    ¥1090
  • 其他:

产品详情

  • Uniprot No.:
  • 基因名:
  • 别名:
    GALR3; GALNR3; Galanin receptor type 3; GAL3-R; GALR-3
  • 宿主:
    Rabbit
  • 反应种属:
    Human
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human GALR3.
  • 免疫原种属:
    Homo sapiens (Human)
  • 标记方式:
    Non-conjugated
  • 抗体亚型:
    IgG
  • 纯化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式:
    Liquid
  • 应用范围:
    WB, IF, ELISA
  • 推荐稀释比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

靶点详情

  • 功能:
    Receptor for the hormone galanin. Receptor for the hormone spexin-1.
  • 基因功能参考文献:
    1. GAL and its receptor GALR3 are differentially methylated and expressed in brains of major depressive disorder subjects in a region- and sex-specific manner. PMID: 27940914
    2. Data from ligand-receptor interaction studies suggest that human spexin-1 and zebrafish spexin-2 activate galanin receptors GALR2/GALR3 (but not GALR1); thus spexins appear to be natural ligands for human/Xenopus/zebrafish GALR2/GALR3. PMID: 24517231
    3. Variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events. PMID: 24706871
    4. The results suggest that GalR3, a receptor for the neuroendocrine peptide galanin, is a potential marker for relapsing pituitary tumors. PMID: 22889491
    5. Mutated human GalR3 receptors are tested with competitive binding analysis in vitro, identifying six different sites in GalR3 that determine binding to galanin. PMID: 20817064
    6. Elevated expression of galanin receptors in childhood neuroblastic tumors. PMID: 11867941
    7. GALR3 showed a significant association with alcoholism that was driven by one SNP (rs3,091,367). PMID: 17083333

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  • 亚细胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 数据库链接:

    HGNC: 4134

    OMIM: 603692

    KEGG: hsa:8484

    STRING: 9606.ENSP00000249041

    UniGene: Hs.158353