FNDC4 Antibody, Biotin conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) FNDC4 Polyclonal antibody
Uniprot No.：

Q9H6D8
基因名：

FNDC4
别名：

Fibronectin type III domain containing 4 antibody; Fibronectin type III domain containing protein 4 antibody; Fibronectin type III domain-containing protein 4 antibody; Fibronectin type III repeat containing protein 1 antibody; Fibronectin type III repeat-containing protein 1 antibody; FLJ22362 antibody; FNDC 4 antibody; FNDC4 antibody; FNDC4_HUMAN antibody; FRCP 1 antibody; FRCP1 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Fibronectin type III domain-containing protein 4 protein (45-167AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

Biotin
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.
基因功能参考文献：
1. FNDC4 as a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases. PMID: 27066907
2. Reports the cloning, expression and subcellular localization of the related mouse protein. PMID: 12384288
亚细胞定位：

Membrane; Single-pass type I membrane protein. Secreted.
组织特异性：

Up-regulated in colon cells of patients with inflammatory bowel disease (IBD).
数据库链接：

HGNC: 20239

OMIM: 611905

KEGG: hsa:64838

STRING: 9606.ENSP00000264703

UniGene: Hs.27836