FEZF1 Antibody, HRP conjugated

中文名称：

FEZF1兔多克隆抗体, HRP偶联
货号：

CSB-PA008602LB01HU
规格：

￥880
其他：

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产品名称：

Rabbit anti-Homo sapiens (Human) FEZF1 Polyclonal antibody
Uniprot No.：

A0PJY2
基因名：

FEZF1
别名：

FEZ antibody; FEZ family zinc finger 1 antibody; Fez family zinc finger protein 1 antibody; fez like antibody; fezf1 antibody; FEZF1_HUMAN antibody; Zinc finger protein 312 like antibody; Zinc finger protein 312B antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Fez family zinc finger protein 1 protein (1-115AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors.
基因功能参考文献：
1. FEZF1 was significantly increased in glioma tissues. Over-expressed FIZF1 was associated with reduced survival. PMID: 30030762
2. loss of FEZF1 impairs the pluripotency exit of hESCs during neural specification, which partially explains the neural induction defect caused by FEZF1 deletion. PMID: 29318501
3. FEZF1plays a novel role in regulating the malignant behavior of glioma stem cells as a part of Linc00152/miR-103a-3p/FEZF1/CDC25A axis.FEZF1 up-regulated the promoter activities and bound to the promoters of CDC25A in glioma stem cells. PMID: 28651608
4. High expression of long noncoding RNA FEZF1 was significantly associated with later stage and higher grade of gastric cancer. PMID: 29239821
5. SEZ6L, HISPPD1, FEZF1, SAMD11 gene variants may be associated with autism spectrum disorder. PMID: 26204995
6. Fezf1 and Fezf2 accomplish both independent and redundant functions across diverse tissue and cell types. [Review] PMID: 24913420
7. Mutations in FEZF1 cause Kallmann syndrome. PMID: 25192046
8. the aberrant expression of ZNF312b promotes gastric tumorigenesis through epigenetic modification of its promoter region and provides a molecular mechanism for ZNF312b expression to contribute to the progression of gastric cancer. PMID: 21170990
9. Study is the first to report that ZNF312b, a novel transcription factor, was associated with tumorigenicity of gastric cancer. PMID: 19318583
10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19401682
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相关疾病：

Hypogonadotropic hypogonadism 22 with or without anosmia (HH22)
亚细胞定位：

Nucleus.
蛋白家族：

Krueppel C2H2-type zinc-finger protein family
组织特异性：

Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2- to 20-fold increase is found in over 50% of gastric cancer tissues.
数据库链接：

HGNC: 22788

OMIM: 613301

KEGG: hsa:389549

STRING: 9606.ENSP00000411145

UniGene: Hs.553970

FEZF1 Antibody, HRP conjugated

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