FBXO28 Antibody, Biotin conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) FBXO28 Polyclonal antibody
Uniprot No.：

Q9NVF7
基因名：

FBXO28
别名：

CENP 30 antibody; Centromere protein 30 antibody; F box only protein 28 antibody; F box protein 28 antibody; F-box only protein 28 antibody; Fbx28 antibody; FBX28_HUMAN antibody; FBXO28 antibody; FLJ10766 antibody; KIAA0483 antibody; OTTHUMP00000035597 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human F-box only protein 28 protein (251-368AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

Biotin
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
基因功能参考文献：
1. It was shown on human primary islets that FBXO28 improves pancreatic beta-cell survival under diabetogenic conditions without affecting insulin secretion. PMID: 29587369
2. Expression levels of TP53BP2, FBXO28, and FAM53A genes were associated with patient survival specifically in ER-positive, TP53-mutated tumors. PMID: 28179588
3. Fbxo28 regulates topoisomerase IIalpha decatenation activity and plays an important role in maintaining genomic stability. PMID: 27754753
4. Refinement of the critical region of 1q41q42 microdeletion syndrome identifies FBXO28 as a candidate causative gene for intellectual disability and seizures. PMID: 24357076
5. Study identified F-box protein, FBXO28 that controls MYC-dependent transcription by non-proteolytic ubiquitylation. Depletion of FBXO28 or overexpression of an F-box mutant unable to support MYC ubiquitylation results in an impairment of MYC-driven transcription, transformation and tumourigenesis. PMID: 23776131
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亚细胞定位：

Chromosome, centromere, kinetochore.
数据库链接：

HGNC: 29046

OMIM: 609100

KEGG: hsa:23219

STRING: 9606.ENSP00000355827

UniGene: Hs.64691