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  4. FBXO22 Antibody

FBXO22 Antibody

说明书
  • 中文名称：
    FBXO22兔多克隆抗体
  • 货号：
    CSB-PA854115ESR1HU
  • 规格：
    ￥440
  • 图片：
    • Western Blot
      Positive WB detected in:Mouse Brain tissue lysate(20µg)
      All lanes: FBXO22 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 45kDa
      Observed band size: 45 kDa
      Exposure time: 10s
    • Western Blot
      Positive WB detected in: Hela whole cell lysate(20µg), MCF7 whole cell lysate(20µg), HepG2 whole cell lysate(20µg), 293 whole cell lysate(20µg), JK whole cell lysate(20µg), K562 whole cell lysate(20µg), A549 whole cell lysate(20µg), A431 whole cell lysate(20µg), U251 whole cell lysate(20µg)
      All lanes: FBXO22 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 45 kDa
      Observed band size: 45 kDa
      Exposure time: 10s
    • IHC image of CSB-PA854115ESR1HU diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
    • IHC image of CSB-PA854115ESR1HU diluted at 1:200 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FBXO22 Polyclonal antibody
  • Uniprot No.：
    Q8NEZ5
  • 基因名：
    FBXO22
  • 别名：
    0610033L19Rik antibody; 1600016C16Rik antibody; F box only protein 22 antibody; F box protein 22 antibody; F box protein FBX22p44 antibody; F-box only protein 22 antibody; F-box protein FBX22p44 antibody; FBX22 antibody; FBX22_HUMAN antibody; FBXO 22 antibody; FBXO22 antibody; FIST domain containing 1 antibody; FISTC1 antibody; FLJ13986 antibody; MGC124731 antibody; MGC31799 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Synthesized peptide derived from human FBX22 AA range: 182-232
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:3000
    IHC 1:100-1:300
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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FBXO22 antibodies

FBXO22 Proteins

靶点详情

  • 功能：
    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.
  • 基因功能参考文献：
    1. Data show that FBXO22 mediated the polyubiquitination and degradation of CD147 by interacting with CD147 intracellular domain (CD147-ICD). PMID: 28117675
    2. Authors demonstrate that F-box only protein 22 (FBXO22) interacts with and thereby destabilizes KLF4 via polyubiquitination. As a result, FBXO22 could promote HCC cells proliferation. PMID: 26087183
    3. Results indicate that SCF(Fbxo22)-KDM4A is an E3 ubiquitin ligase that targets methylated p53 and regulates key senescent processes. PMID: 26868148
    4. FBXO22 protein is required for optimal synthesis of NMDA receptor coagonist D-serine by interacting with serine racemase, activating it, and preventing its targeting to membranes. PMID: 25336657
    5. we determined that the phage-encoded GogB effector protein in Salmonella targets the host SCF E3 type ubiquitin ligase through an interaction with Skp1 and the human F-box only 22 (FBXO22) protein PMID: 22761574
    6. FBXO22 is a key regulator of histone methylation marks, namely, H3K9 and H3K36 methylation, through the regulation of KDM4A protein levels. PMID: 21768309

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  • 亚细胞定位：
    Cytoplasm, myofibril, sarcomere, Z line.
  • 组织特异性：
    Predominantly expressed in liver, also enriched in cardiac muscle.
  • 数据库链接：

    HGNC: 13593

    OMIM: 609096

    KEGG: hsa:26263

    STRING: 9606.ENSP00000307833

    UniGene: Hs.591115

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