FAM89B Antibody, HRP conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) FAM89B Polyclonal antibody
Uniprot No.：

Q8N5H3
基因名：

FAM89B
别名：

FAM89B antibody; Lrap25 antibody; Leucine repeat adapter protein 25 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Leucine repeat adapter protein 25 protein (1-162AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

HRP
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
基因功能参考文献：
1. the functional relevance of the LRAP25-MRCK complex in LIMK1-cofilin signaling and the importance of LRAP adaptors as key determinants of MRCK cellular localization and downstream specificities. PMID: 25107909
2. identified two human genes, Mtvr1 and Mtvr2, encoding proteins highly related to the Mouse Mammary Tumor Virus receptor [Mtvr1] [Mtvr2] PMID: 11958456
亚细胞定位：

[Isoform 3]: Cytoplasm. Cell projection, lamellipodium.
蛋白家族：

FAM89 family
数据库链接：

HGNC: 16708

OMIM: 616128

KEGG: hsa:23625

UniGene: Hs.731854