Your Good Partner in Biology Research

中文简体

CSF2｜ CTLA4｜ DLL3｜ EGFR｜ IL4｜ IL4R｜ LAG3｜ MSTN｜ NECTIN4｜ NT5E｜ SEZ6｜ TM4SF1｜ TNFSF13｜ TPO

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. ELP3 Antibody, FITC conjugated

ELP3 Antibody, FITC conjugated

说明书
  • 中文名称：
    ELP3兔多克隆抗体, FITC偶联
  • 货号：
    CSB-PA884499LC01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ELP3 Polyclonal antibody
  • Uniprot No.：
    Q9H9T3
  • 基因名：
    ELP3
  • 别名：
    DKFZp761L098 antibody; Elongation protein 3 homolog (S. cerevisiae) antibody; Elongation protein 3 homolog antibody; ELONGATION PROTEIN 3; S. CEREVISIAE; HOMOLOG OF antibody; elongator acetyltransferase complex subunit 3 antibody; Elongator complex protein 3 antibody; elp3 antibody; ELP3_HUMAN antibody; FLJ10422 antibody; hELP3 antibody; Hypothetical protein DKFZp761L098 antibody; Kat9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Elongator complex protein 3 protein (1-85AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    FITC
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

相关产品

ELP3 antibodies

ELP3 Proteins

靶点详情

  • 功能：
    Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex.
  • 基因功能参考文献：
    1. and CTU1/2, partner enzymes in U34 methoxycarbonylmethyl-2-thio tRNA modification, are up-regulated in human breast cancers and sustain metastasis. PMID: 27811057
    2. Promoter hypermethylation is an important mechanism of the transcriptional inactivation of ELP3 in invasive ductal breast carcinoma. PMID: 25148870
    3. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. PMID: 24769394
    4. data suggest that hElp3 can regulate the transcription of HSP70 gene, and the HAT domain of hElp3 is essential for this function PMID: 22216241
    5. The results of this study uncover a novel role for Elp3 in the regulation of synaptic bouton expansion during neurogenesis that may be linked with a requirement for sleep. PMID: 20626565
    6. Elp3 promotes the acetylation of alpha-tubulin in microtubules in neurological disorders. PMID: 20036197
    7. We used hELP3 antisense oligonucl. to knock down hELP3 gene. The results showed that reduction of hELP3 mRNA and protein caused a suppression of HSP70-2 and histone H3 hypoacetylation. PMID: 17558451
    8. Allelic variants of ELP3 were associated with amyotrophic lateral sclerosis in three populations comprising 1483 people. PMID: 18996918
    9. ELP3 localises to mitochondria in HeLa cells, actin-like filaments, and actin-rich sites at the edges of spreading cells. This suggests that ELP3 and the ELONGATOR complex may play a role in mitochondrial function, actin organisation, and cell motility. PMID: 19429107

    显示更多

    收起更多

  • 相关疾病：
    ELP3 genetic variations may be associated with an increased risk for neurodegeneration and motor neuron diseases.
  • 亚细胞定位：
    Cytoplasm. Nucleus.; [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.
  • 蛋白家族：
    ELP3 family
  • 组织特异性：
    Expressed in the cerebellum and spinal motor neurons.
  • 数据库链接：

    HGNC: 20696

    OMIM: 612722

    KEGG: hsa:55140

    STRING: 9606.ENSP00000256398

    UniGene: Hs.491336

Most popular with customers

产品中心
特别关注


X
九游平台-九游(中国) | 米兰体育-米兰体育（中国） | 开云手机在线登陆入口 | 江南官方体育网页版 | 开云网页版 | 开云官方在线入口 | 开云电子体育 | 开云官方链接 | 江南网页版页面登录 |