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  4. ECSCR Antibody, Biotin conjugated

ECSCR Antibody, Biotin conjugated

说明书
  • 中文名称：
    ECSCR兔多克隆抗体, Biotin偶联
  • 货号：
    CSB-PA007385LD01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ECSCR Polyclonal antibody
  • Uniprot No.：
    Q19T08
  • 基因名：
    ECSCR
  • 别名：
    ECSCR antibody; ECSCR_HUMAN antibody; Endothelial cell-specific chemotaxis regulator antibody; Endothelial cell-specific molecule 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Endothelial cell-specific chemotaxis regulator protein (25-124AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Biotin
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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ECSCR antibodies

ECSCR Proteins

靶点详情

  • 功能：
    Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.
  • 基因功能参考文献：
    1. Low expression level of ECSCR is associated with evasive resistance and disease progression in cancer. PMID: 26956051
    2. identification of three novel full-length splice variants potentially encoding different protein isoforms PMID: 23147565
    3. Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. PMID: 23393131
    4. ECSM2 modulated bFGF-directed endothelial cell motility via the FGF receptor (FGFR)-extracellular regulated kinase (ERK)-focal adhesion kinase (FAK) pathway. PMID: 21720547
    5. Characterize a novel cell surface protein ECSM2 that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. PMID: 18556573
    6. ECSM2 is involved in cell-shape changes and actin cytoskeletal rearrangement, suppresses tyrosine phosphorylation signaling and ECSM2 can cross-talk with EGFR to attenuate the EGF-induced cell migration. PMID: 19267780
    7. Knockdown of ARIA in HUVECs significantly reduced endothelial apoptosis without affecting either cell migration or proliferation. ARIA knockdown significantly increased inhibitor of apoptosis cIAP-1 and cIAP-2 protein expression PMID: 19416853
    8. Observational study of gene-disease association. (HuGE Navigator) PMID: 19240791

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasm.
  • 蛋白家族：
    ECSCR family
  • 组织特异性：
    Highest expression in endothelial cells. Also detected in vascular smooth muscle, macrophages, lymphocytes, and mast cells.
  • 数据库链接：

    HGNC: 35454

    KEGG: hsa:641700

    UniGene: Hs.483538

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