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  4. DPEP1 Antibody, FITC conjugated

DPEP1 Antibody, FITC conjugated

说明书
  • 中文名称：
    DPEP1兔多克隆抗体, FITC偶联
  • 货号：
    CSB-PA007123LC01HU
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DPEP1 Polyclonal antibody
  • Uniprot No.：
    P16444
  • 基因名：
    DPEP1
  • 别名：
    Dehydropeptidase-I antibody; Dipeptidase 1 (renal) antibody; Dipeptidase 1 antibody; DPEP1 antibody; DPEP1_HUMAN antibody; hRDP antibody; MBD1 antibody; MDP antibody; Microsomal dipeptidase antibody; RDP antibody; Renal dipeptidase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Dipeptidase 1 protein (23-252AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    FITC
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Antigen Affinity purified & Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶点详情

  • 功能：
    Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics.; Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.
  • 基因功能参考文献：
    1. The results suggest that DPEP1 promotes cancer metastasis by regulating E-cadherin plasticity and that it might be a potential therapeutic target for preventing the progression of colon cancer. PMID: 26824987
    2. In this study, we present an analysis of Neanderthal introgression at the dipeptidase 1 gene, DPEP1. PMID: 26392408
    3. Dipeptidase 1 has been identified as an excellent marker of high-grade IEN and CRC, and may thus be applied for screening of early neoplastic lesions and for prognostic stratification. PMID: 23839495
    4. DPEP1 plays a role in pancreatic cancer aggressiveness. PMID: 22363658
    5. DPEP1 is expressed in the early stages of colon carcinogenesis and affects cancer cell invasiveness. PMID: 20824289
    6. we identified a novel immunohistochemical marker, dipeptidase 1, to distinguish primary mucinous ovarian cancers from ovarian metastasis of colorectal cancers. PMID: 21076463
    7. Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis PMID: 12144777
    8. DPEP1 has a role in colorectal carcinoma PMID: 15145522

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  • 亚细胞定位：
    Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Metallo-dependent hydrolases superfamily, Peptidase M19 family
  • 组织特异性：
    Expressed in lung and kidneys.
  • 数据库链接：

    HGNC: 3002

    OMIM: 179780

    KEGG: hsa:1800

    STRING: 9606.ENSP00000261615

    UniGene: Hs.109

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