DOCK10 Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) DOCK10 Polyclonal antibody
Uniprot No.：

Q96BY6
基因名：

DOCK10
别名：

DOCK10 antibody; KIAA0694 antibody; ZIZ3Dedicator of cytokinesis protein 10 antibody; Zizimin-3 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Dedicator of cytokinesis protein 10 protein (1645-2186AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
基因功能参考文献：
1. T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms PMID: 21514340
2. Dock10 could represent a point of convergence for interleukin 4 signalling and small Rho GTPase function in B cells. PMID: 18499258
3. Silencing DOCK10 expression in melanoma promotes conversion to mesenchymal migration and is associated with decreased MLC2 phosphorylation and increased Rac1 activation. PMID: 18835169
亚细胞定位：

Nucleus. Cytoplasm. Cell projection, dendritic spine.
蛋白家族：

DOCK family
组织特异性：

Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
数据库链接：

HGNC: 23479

OMIM: 611518

KEGG: hsa:55619

STRING: 9606.ENSP00000258390

UniGene: Hs.46578