DMXL2 Antibody, Biotin conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) DMXL2 Polyclonal antibody
Uniprot No.：

Q8TDJ6
基因名：

DMXL2
别名：

DmX-like protein 2 antibody; Dmxl2 antibody; DMXL2_HUMAN antibody; KIAA0856 antibody; Rabconnectin-3 antibody; RC3 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human DmX-like protein 2 protein (2471-2657AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

Biotin
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes.
基因功能参考文献：
1. Data indicated that the p.Arg2417His variant in DMXL2 is associated with dominant, nonsyndromic hearing loss and suggested an important role of DMXL2 in inner ear function. PMID: 27657680
2. authors demonstrate that DMXL2 is a transmembrane protein with a potential extra-cellular domain. These findings identify DMXL2 as a novel, functional biomarker for ERalpha positive breast cancer. PMID: 26093085
3. Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in humans and mice. PMID: 25248098
4. an important role for Rabconnectin-3 and V-ATPase activity in the Notch signaling pathway in mammalian cells. PMID: 20810660
相关疾病：

Polyendocrine-polyneuropathy syndrome (PEPNS); Deafness, autosomal dominant, 71 (DFNA71)
亚细胞定位：

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle.
数据库链接：

HGNC: 2938

OMIM: 612186

KEGG: hsa:23312

STRING: 9606.ENSP00000441858

UniGene: Hs.511386