CIART Antibody

中文名称：

CIART兔多克隆抗体
货号：

CSB-PA850790LA01HU
规格：

￥440
图片：
Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA850790LA01HU at dilution of 1:100
其他：

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) CIART Polyclonal antibody
Uniprot No.：

Q8N365
基因名：

CIART
别名：

CIART antibody; C1orf51Circadian-associated transcriptional repressor antibody; ChIP-derived repressor of network oscillator antibody; Chrono antibody; Computationally highlighted repressor of the network oscillator antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Circadian-associated transcriptional repressor protein (1-385AA)
免疫原种属：

Homo sapiens (Human)

标记方式：

Non-conjugated

本页面中的产品，CIART Antibody (CSB-PA850790LA01HU)，的标记方式是Non-conjugated。对于CIART Antibody，我们还提供其他标记。见下表：

标记方式	货号	产品名称	应用
HRP	CSB-PA850790LB01HU	CIART Antibody, HRP conjugated	ELISA
FITC	CSB-PA850790LC01HU	CIART Antibody, FITC conjugated
Biotin	CSB-PA850790LD01HU	CIART Antibody, Biotin conjugated	ELISA

克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA, IHC
推荐稀释比：

Application Recommended Dilution

IHC 1:20-1:200
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response.
基因功能参考文献：
1. Study shows that:1- Chrono is a circadian clock gene whose transcription exhibits a robust circadian oscillation. 2- Is is a repressor of circadian transcriptional/translational feedback loops. 3- It may function to link epigenetic control mechanisms to stress responses. [review] PMID: 28010116
亚细胞定位：

Nucleus. Nucleus, PML body.
数据库链接：

HGNC: 25200

OMIM: 615782

KEGG: hsa:148523

STRING: 9606.ENSP00000290363

UniGene: Hs.54680