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  4. CFHR2 Antibody, HRP conjugated

CFHR2 Antibody, HRP conjugated

说明书
  • 中文名称：
    CFHR2兔多克隆抗体, HRP偶联
  • 货号：
    CSB-PA13817B0Rb
  • 规格：
    ￥880
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CFHR2 Polyclonal antibody
  • Uniprot No.：
    P36980
  • 基因名：
    CFHR2
  • 别名：
    CFHL2 antibody; CFHR2 antibody; Complement factor H related protein 2 antibody; Complement factor H-related 2 antibody; Complement factor H-related protein 2 antibody; DDESK59 antibody; Factor H-related gene 2 antibody; FHR 2 antibody; FHR-2 antibody; FHR2 antibody; FHR2_HUMAN antibody; H factor (complement)-like 3 antibody; H factor like 3 antibody; H factor like protein 2 antibody; H factor-like 3 antibody; H factor-like protein 2 antibody; HFL3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Complement factor H-related protein 2 protein (20-269AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    HRP
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶点详情

  • 功能：
    Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.
  • 基因功能参考文献：
    1. Studies indicate an association between CFHR2-rs2986127 and acute anterior uveitis (AAU) diagnosis. PMID: 27306586
    2. Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR2] PMID: 27196323
    3. Thus CFHR2 likely acts in concert with factor H, as CFHR2 inhibits convertases while simultaneously allowing factor H assisted degradation by factor I. PMID: 24260121
    4. A hybrid CFHR2-CFHR5 plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H-mediated convertase decay. PMID: 24334459
  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed by the liver and secreted in plasma.
  • 数据库链接：

    HGNC: 4890

    OMIM: 600889

    KEGG: hsa:3080

    STRING: 9606.ENSP00000356385

    UniGene: Hs.632450

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