CAPN6 Antibody, Biotin conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) CAPN6 Polyclonal antibody
Uniprot No.：

Q9Y6Q1
基因名：

CAPN6
别名：

CALP M antibody; Calpain-6 antibody; Calpain-like protease X-linked antibody; Calpamodulin antibody; CalpM antibody; CAN6_HUMAN antibody; CANP X antibody; CANPX antibody; CAPN 6 antibody; Capn6 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Calpain-6 protein (195-494AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

Biotin
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues.
基因功能参考文献：
1. High CAPN6 expression is associated with liver cancer. PMID: 26375440
2. CAPN6 promotes atherogenicity in inflamed macrophages by disturbing CWC22/EJC systems. PMID: 27525442
3. syndecan-2 exerts its pro-apoptotic function through modulation of the endothelin-1/NFkappaB signaling and through downregulation of calpain-6. PMID: 21681744
4. results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis PMID: 18657900
亚细胞定位：

Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.
蛋白家族：

Peptidase C2 family
组织特异性：

Expressed only in placenta.
数据库链接：

HGNC: 1483

OMIM: 300146

KEGG: hsa:827

STRING: 9606.ENSP00000317214

UniGene: Hs.496593