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  4. BCAR3 Antibody

BCAR3 Antibody

说明书
  • 中文名称：
    BCAR3兔多克隆抗体
  • 货号：
    CSB-PA060303
  • 规格：
    ￥1090
  • 其他：

产品详情

  • Uniprot No.：
    O75815
  • 基因名：
    BCAR3
  • 别名：
    BCAR 3 antibody; BCAR3 antibody; BCAR3_HUMAN antibody; Breast cancer anti estrogen resistance 3 antibody; Breast cancer anti estrogen resistance protein 3 antibody; Breast cancer anti-estrogen resistance protein 3 antibody; Breast cancer antiestrogen resistance 3 antibody; dJ1033H22.2 antibody; dJ1033H22.2 breast cancer anti estrogen resistance 3 antibody; dJ1033H22.2 breast cancer antiestrogen resistance 3 antibody; KIAA0554 antibody; Novel SH2 containing protein 2 antibody; Novel SH2-containing protein 2 antibody; NSP 2 antibody; NSP2 antibody; SH2 containing protein Nsp2 antibody; SH2 domain containing protein 3B antibody; SH2 domain-containing protein 3B antibody; SH2D3B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human BCAR3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
    Immunofluorescence (IF) Protocol
    ELISA Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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BCAR3 Proteins

靶点详情

  • 功能：
    Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis. Promotes insulin-mediated membrane ruffling. In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity. May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction. Regulates EGF-induced DNA synthesis. Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling. Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA. Positively regulates integrin-induced tyrosine phosphorylation of BCAR1. Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS. However, in a contrasting study, lacks GEF activity towards RAP1.
  • 基因功能参考文献：
    1. BCAR3 is an essential interactor and mediator of HEF1-induced migration. PMID: 25817040
    2. BCAR3 acts as a putative suppressor of breast cancer progression by inhibiting the prometastatic TGFbeta/Smad signaling pathway in invasive breast tumors. PMID: 25499443
    3. BCAR1 and BCAR3 scaffolding proteins have roles in cell signaling and antiestrogen resistance PMID: 24584939
    4. Taken together, these results demonstrated that BCAR3 plays an important role in the signaling pathways of insulin leading to cell cycle progression and cytoskeleton reorganization, but not GLUT4 translocation. PMID: 24216110
    5. BCAR3 promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells. PMID: 23762409
    6. BCAR3 expression may regulate Src signaling in a BCAR3-p130(cas) complex-dependent fashion by altering the ability of the Src SH3 domain to bind the p130(cas) SBD PMID: 22711540
    7. BCAR3-p130Cas complex formation is not required for BCAR3-mediated anti-estrogen resistance, Rac activation or discohesion of epithelial breast cancer cells PMID: 21262352
    8. the c-Src/Cas/BCAR3 signaling axis is a prominent regulator of c-Src activity, which in turn controls cell behaviors that lead to aggressive and invasive breast tumor phenotypes PMID: 19940159
    9. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner PMID: 15671247
    10. BCAR3 and NSP1 are more highly expressed than SH2D3C (SHEP1) in breast cancer cells, and the expression patterns suggest differential roles for the three genes during breast cancer progression. PMID: 17270363
    11. BCAR3 induces anti-estrogen resistance in breast tumor cell lines by altering cell-cell/cell-matrix interactions and cyclin D1 promoter activity. PMID: 17427198
    12. the spatial and temporal regulation of BCAR3/p130(Cas) interactions within the cell is important for controlling breast cancer cell motility PMID: 17616674
    13. BCAR3 protein, through its SH2 domain, is involved in the signaling pathways of EGF leading to cell cycle progression; BCAR3 itself is part of a mitogenic signaling pathway. PMID: 18722344
    14. The expression of breast cancer anti-estrogen resistance 3 results in basal serine phosphorylation of Crk-Associated Substrate Protein that normally occurs during adhesion of breast cancer cells to fibronectin. PMID: 19454314

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  • 亚细胞定位：
    Cytoplasm. Cell junction, focal adhesion.
  • 组织特异性：
    Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.
  • 数据库链接：

    HGNC: 973

    OMIM: 604704

    KEGG: hsa:8412

    STRING: 9606.ENSP00000260502

    UniGene: Hs.36958

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