B3GNT5 Antibody

产品详情

Uniprot No.：

Q9BYG0
基因名：

B3GNT5
别名：

B3GNT5Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase antibody; EC 2.4.1.206 antibody; Lactotriaosylceramide synthase antibody; Lc(3)Cer synthase antibody; Lc3 synthase antibody; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5 antibody; BGnT-5 antibody; Beta-1,3-Gn-T5 antibody; Beta-1,3-N-acetylglucosaminyltransferase 5 antibody; Beta3Gn-T5 antibody
宿主：

Rabbit
反应种属：

Human,Mouse,Rat
免疫原：

Human B3GNT5
免疫原种属：

Homo sapiens (Human)
抗体亚型：

IgG
纯化方式：

Antigen Affinity purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
产品提供形式：

Liquid
应用范围：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
基因功能参考文献：
1. bone marrow samples of acute myeloid leukemia patients had 16-fold higher expression of B3GNT5 than those of healthy donors PMID: 22411838
2. Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x PMID: 18483624
亚细胞定位：

Golgi apparatus membrane; Single-pass type II membrane protein.
蛋白家族：

Glycosyltransferase 31 family
组织特异性：

Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus.
数据库链接：

HGNC: 15684

OMIM: 615333

KEGG: hsa:84002

STRING: 9606.ENSP00000316173

UniGene: Hs.718506