ART1 Antibody

中文名称：

ART1兔多克隆抗体
货号：

CSB-PA002155LA01HU
规格：

￥440
图片：
IHC image of CSB-PA002155LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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产品名称：

Rabbit anti-Homo sapiens (Human) ART1 Polyclonal antibody
Uniprot No.：

P52961
基因名：

ART1
别名：

ART1GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 antibody; EC 2.4.2.31 antibody; ADP-ribosyltransferase C2 and C3 toxin-like 1 antibody; ARTC1 antibody; Mono(ADP-ribosyl)transferase 1 antibody; CD antigen CD296 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 protein (46-142AA )
免疫原种属：

Homo sapiens (Human)

标记方式：

Non-conjugated

本页面中的产品，ART1 Antibody (CSB-PA002155LA01HU)，的标记方式是Non-conjugated。对于ART1 Antibody，我们还提供其他标记。见下表：

标记方式	货号	产品名称	应用
HRP	CSB-PA002155LB01HU	ART1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002155LC01HU	ART1 Antibody, FITC conjugated
Biotin	CSB-PA002155LD01HU	ART1 Antibody, Biotin conjugated	ELISA

克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA, IHC
推荐稀释比：

Application Recommended Dilution

IHC 1:200-1:500
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

Has ADP-ribosyltransferase activity toward GLP1R.
基因功能参考文献：
1. Our data suggest that ART1 could regulate EMT by regulating the RhoA/ROCK1/AKT/beta-catenin pathway and its downstream factors (snail1, vimentin, N-cadherin and E-cadherin) and that it therefore plays an important role in the progression of colon carcinoma. PMID: 27277835
2. up-regulation of ART1 expression is associated with the aggressiveness of glioma. PMID: 27466078
3. Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway PMID: 26847718
4. The altered function and expression of P2X7 and ART1 in the human CD39+ Treg or CD39- Treg cells could participate in the resistance against cell death induced by ATP or NAD. PMID: 26307000
5. This study provides evidence that ARTC1 is activated during the endoplasmic-reticulum stress response, which results in acute ADP-ribosylation of GRP78/BiP paralleling translational inhibition. PMID: 25292337
6. ADP-ribosylation of HNP-1 appears to be primarily an activity of ART1 and occurs in inflammatory conditions and disease PMID: 16627471
7. ADPRT Ala762Val polymorphism may play a role in the etiology of squamous cell carcinoma of the head and neck or in linkage disequilibrium with other untyped protective alleles. PMID: 17614107
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亚细胞定位：

Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

Arg-specific ADP-ribosyltransferase family
数据库链接：

HGNC: 723

OMIM: 601625

KEGG: hsa:417

STRING: 9606.ENSP00000250693

UniGene: Hs.382188

ART1 Antibody

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