ARHGAP11B Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) ARHGAP11B Polyclonal antibody
Uniprot No.：

Q3KRB8
基因名：

ARHGAP11B
别名：

ARHGAP11B antibody; FAM7B1 antibody; Rho GTPase-activating protein 11B antibody; Protein FAM7B1 antibody; Rho-type GTPase-activating protein 11B antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Rho GTPase-activating protein 11B protein (99-231AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development.
基因功能参考文献：
1. The data also demonstrate that a single C-->G base substitution underlies the ARHGAP11B-mediated basal progenitor amplification implicated in neocortex expansion. PMID: 27957544
2. ARHGAP11B may have contributed to evolutionary expansion of human neocortex. PMID: 25721503
亚细胞定位：

Mitochondrion matrix.
数据库链接：

HGNC: 15782

OMIM: 616310

KEGG: hsa:89839

STRING: 9606.ENSP00000392760

UniGene: Hs.659621