ARHGAP10 Antibody

中文名称：

ARHGAP10兔多克隆抗体
货号：

CSB-PA002012LA01HU
规格：

￥440
图片：
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA002012LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA002012LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) ARHGAP10 Polyclonal antibody
Uniprot No.：

A1A4S6
基因名：

ARHGAP10
别名：

Arhgap10 antibody; Graf-related protein 2 antibody; GRAF2 antibody; GTPase regulator associated with focal adhesion kinase 2 antibody; PS GAP antibody; PSGAP antibody; RHG10_HUMAN antibody; Rho GTPase-activating protein 10 antibody; Rho-type GTPase-activating protein 10 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Rho GTPase-activating protein 10 protein (542-744AA)
免疫原种属：

Homo sapiens (Human)

标记方式：

Non-conjugated

本页面中的产品，ARHGAP10 Antibody (CSB-PA002012LA01HU)，的标记方式是Non-conjugated。对于ARHGAP10 Antibody，我们还提供其他标记。见下表：

标记方式	货号	产品名称	应用
HRP	CSB-PA002012LB01HU	ARHGAP10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002012LC01HU	ARHGAP10 Antibody, FITC conjugated
Biotin	CSB-PA002012LD01HU	ARHGAP10 Antibody, Biotin conjugated	ELISA

克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

Liquid
应用范围：

ELISA, IHC, IF
推荐稀释比：

Application Recommended Dilution

IHC 1:20-1:200

IF 1:50-1:200
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.
基因功能参考文献：
1. ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways. PMID: 27010858
2. In the Australian GWAS, one SNP achieved genomewide significance (p < 5 x 10(-8)) for ND (rs964170 in ARHGAP10 on chromosome 4, p = 4.43 x 10(-8)). PMID: 20158304
3. PS-GAP is a novel regulator of caspase-activated PAK-2 PMID: 15471851
亚细胞定位：

Cytoplasm. Cytoplasm, perinuclear region. Cell membrane.
组织特异性：

High levels of expression in heart and skeletal muscle.
数据库链接：

HGNC: 26099

OMIM: 609746

KEGG: hsa:79658

STRING: 9606.ENSP00000336923

UniGene: Hs.368631

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200