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  4. ALDH4A1 Antibody

ALDH4A1 Antibody

说明书
  • 中文名称：
    ALDH4A1兔多克隆抗体
  • 货号：
    CSB-PA001576ESR2HU
  • 规格：
    ￥440
  • 图片：
    • Western blot
      All lanes: ALDH4A1 antibody at 13µg/ml
      Lane 1: K562 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 62, 56, 57 kDa
      Observed band size: 62 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA001576ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001576ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ALDH4A1 Polyclonal antibody
  • Uniprot No.：
    P30038
  • 基因名：
    ALDH4A1
  • 别名：
    AL4A1_HUMAN antibody; aldehyde dehydrogenase 4 antibody; aldehyde dehydrogenase 4 family; member A1 antibody; Aldehyde dehydrogenase family 4 member A1 antibody; Aldehyde dehydrogenase; family 4; subfamily A; member 1 antibody; ALDH4 antibody; aldh4a1 antibody; Delta 1 pyrroline 5 carboxylate dehydrogenase; mitochondrial antibody; Delta-1-pyrroline-5-carboxylate dehydrogenase antibody; L-glutamate gamma-semialdehyde dehydrogenase antibody; mitochondrial antibody; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase antibody; P5C dehydrogenase antibody; P5CD antibody; P5CDh antibody; P5CDhL antibody; P5CDhS antibody; Pyrroline-5-carboxylate dehydrogenase antibody; RP11 128M10.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial protein (354-563AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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ALDH4A1 antibodies

ALDH4A1 Proteins

靶点详情

  • 功能：
    Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
  • 基因功能参考文献：
    1. the impact of the hyperprolinemia-associated mutation of Ser352 to Leu on the structure and catalytic properties of the P5CDH PMID: 22516612
    2. ALDH4 is a p53-inducible gene with a protective role in cellular stresses PMID: 14986171
    3. ALDH4 is transcriptionally induced by p53. PMID: 14986171
  • 相关疾病：
    Hyperprolinemia 2 (HYRPRO2)
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Aldehyde dehydrogenase family
  • 组织特异性：
    Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.
  • 数据库链接：

    HGNC: 406

    OMIM: 239510

    KEGG: hsa:8659

    STRING: 9606.ENSP00000290597

    UniGene: Hs.77448

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