AGO4 Antibody, Biotin conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) AGO4 Polyclonal antibody
Uniprot No.：

Q9HCK5
基因名：

AGO4
别名：

Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4), AGO4, EIF2C4 KIAA1567
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Protein argonaute-4 protein (716-861aa)
免疫原种属：

Homo sapiens (Human)
标记方式：

Biotin
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).
基因功能参考文献：
1. Chimeras with Ago4 N-terminal domains were defective in RISC activation & sometimes also in RNA loading. This highlights the pleiotropic role of the Ago N domain & emphasizes the unique position of human Ago4 within the Ago protein family. PMID: 23748378
2. EIF2C4 protein is expressed in differentiating and terminally differentiated N-type cells more than in S- and I-type cells PMID: 19393748
亚细胞定位：

Cytoplasm, P-body.
蛋白家族：

Argonaute family, Ago subfamily
数据库链接：

HGNC: 18424

OMIM: 607356

KEGG: hsa:192670

STRING: 9606.ENSP00000362306

UniGene: Hs.744858