AGFG1 Antibody

中文名称：

AGFG1兔多克隆抗体
货号：

CSB-PA001442GA01HU
规格：

￥3,900
其他：

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Uniprot No.：

P52594
基因名：

AGFG1
别名：

AGFG1 antibody; AGFG1_HUMAN antibody; Arf-GAP domain and FG repeats-containing protein 1 antibody; ArfGAP with FG repeats 1 antibody; AU045498 antibody; C130049H11Rik antibody; C85612 antibody; D730048C23Rik antibody; DKFZp686I15205 antibody; HIV 1 Rev binding protein antibody; HIV-1 Rev-binding protein antibody; HRB antibody; MGC116375 antibody; MGC116938 antibody; MGC116940 antibody; Nucleoporin like protein RIP antibody; Nucleoporin-like protein RIP antibody; RAB antibody; Rev interacting protein antibody; Rev-interacting protein antibody; Rev/Rex activation domain-binding protein antibody; RIP antibody
宿主：

Rabbit
反应种属：

Human,Mouse,Rat
免疫原：

Human AGFG1
免疫原种属：

Homo sapiens (Human)
抗体亚型：

IgG
纯化方式：

Antigen Affinity Purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
产品提供形式：

Liquid
应用范围：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
基因功能参考文献：
1. Necroptotic RIP1 phosphorylation and ubiquitination seem to be tightly coordinated: inhibition or absence of RIP1 kinase activity blocks necroptotic RIP1 ubiquitination, whereas mutation of RIP1 necroptosis-associated ubiquitination site (K115R) dampens RIP1 kinase activity during necroptotic signaling. PMID: 27518435
2. HRB knock-down affected CD4 downregulation induced by Nef but not by HIV-1 Vpu. PMID: 26701340
3. Selenite caused CYLD upregulation via LEF1 and cIAP downregulation, both of which contribute to the degradation of ubiquitin chains on RIP1 and subsequent caspase-8 activation and colorectal tumor cell apoptosis. PMID: 24577083
4. The top primary GWAS association of Airway hyperresponsiveness was in rs6731443 (P-value 2.5E-06) located within the AGFG1 genes. PMID: 23984888
5. Association ofalpha-synuclein with Rab attachment receptor protein and soluble sensitive factor attachment receptors (SNAREs) highlights a key role for membrane transport defects in alpha-synuclein-mediated pathology. PMID: 21439320
6. The authors show that cells lacking functional HRB have significantly reduced production of influenza virus progeny and that this defect results from impaired viral ribonucleoprotein (vRNP) delivery to the plasma membrane. PMID: 21752912
7. hRIP is an essential cellular Rev cofactor, which acts at a previously unanticipated step in HIV-1 RNA export. PMID: 14701878
8. Study demonstrates that the clathrin-mediated endocytosis of the SNARE VAMP7 is directly mediated by Hrb, a clathrin adaptor and ArfGAP. PMID: 18775314
9. HRB is involved in clathrin-dependent endocytosis and recruits TI-VAMP in this process PMID: 18819912
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亚细胞定位：

Nucleus. Cytoplasmic vesicle.
组织特异性：

Ubiquitously expressed.
数据库链接：

HGNC: 5175

OMIM: 600862

KEGG: hsa:3267

STRING: 9606.ENSP00000387282

UniGene: Hs.352962

AGFG1 Antibody

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