Sdc1 Monoclonal Antibody

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中文名称：

Sdc1鼠单克隆抗体
货号：

CSB-MA0208881A0m
规格：

￥1320
其他：

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产品描述：

Sdc1单克隆抗体（CUSABIO货号：CSB-MA0208881A0m）是针对Syndecan-1（CD138）跨膜蛋白开发的科研级试剂，该靶点在细胞信号传导、粘附调控及细胞外基质相互作用中发挥重要功能，尤其在肿瘤微环境调控、上皮细胞分化等领域具有研究价值。本产品采用杂交瘤技术制备，宿主来源为小鼠，经严格质控验证其在大鼠种属中表现出优异反应性，适用于ELISA检测体系。该抗体具有高特异性识别能力，可精准检测Sdc1蛋白的表达水平，为研究肿瘤发生机制、细胞间通讯网络及组织微环境动态变化提供可靠工具。应用场景涵盖体外肿瘤细胞模型分析、信号通路蛋白互作研究以及特定病理状态下Sdc1表达谱的定量检测，适用于分子生物学、细胞生物学等基础研究领域。本产品严格按照科研抗体标准生产，确保实验结果的稳定性和重复性，是探索Sdc1在细胞增殖、迁移及微环境调控中分子机制的理想选择，为癌症研究、再生医学等前沿领域提供高质量的检测支持。
产品名称：

mouse anti-Rattus norvegicus (Rat) Sdc1 monoclonal antibody
Uniprot No.：

P26260
基因名：

Sdc1
别名：

Sdc1 antibody; Synd1 antibody; Syndecan-1 antibody; SYND1 antibody; CD antigen CD138 antibody
宿主：

mouse
反应种属：

Rat
免疫原：

Recombinant Rat Syndecan-1 protein
免疫原种属：

Rattus norvegicus (Rat)
标记方式：

Non-conjugated
克隆类型：

monoclonal
抗体亚型：

IgG1
纯化方式：

>95%,protein G purifed
克隆号：

1B4F4
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
产品提供形式：

liquid
应用范围：

ELISA
Protocols：

ELISA Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
基因功能参考文献：
1. Plasma syndecan-1 and heparan sulfate correlate with microvascular glycocalyx degradation in hemorrhaged rats after different resuscitation fluids. PMID: 27037369
2. down-regulation of Syndecan-1 could inhibit VEGF-VEGFR-2 signaling through regulating internalization of VEGFR-2. PMID: 27075925
3. expression upregulated two months after renal transplantation PMID: 25972509
4. data suggest that after renal transplantation loss of hepatic HS together with increased syndecan-1 shedding hampers lipoprotein binding and uptake by the liver contributing to dyslipidemia PMID: 25154787
5. analysis of the molecular events that drive endocytosis of syndecan-1, a raft-dependent receptor and identification of its novel endocytic motif, MKKK PMID: 23525115
6. The abnormal expression of HSPG may be an important molecular mechanism that leads to the occurrence and development of proteinuria in adriamycin-induced nephropathy rats. PMID: 20506637
7. role in regulatory mechanism of apoptosis PMID: 11979781
8. Syndecan-1 mRNA expression is not modulated by FSH as it would result from the antagonistic effects of increased intracellular cAMP and intracellular calcium levels. PMID: 12135485
9. The major injury-related change, seen in injured brain and cultured glia, was an increase in 2-O-sulphated HS and increased syndecan-1, suggesting novel approaches to modulating scar formation. PMID: 18279312
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亚细胞定位：

Membrane; Single-pass type I membrane protein. Secreted. Secreted, extracellular exosome.
蛋白家族：

Syndecan proteoglycan family
数据库链接：

KEGG: rno:25216

STRING: 10116.ENSRNOP00000008582

UniGene: Rn.11176

Sdc1 Monoclonal Antibody

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