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  4. NBR1 Monoclonal Antibody

NBR1 Monoclonal Antibody

说明书
  • 中文名称：
    NBR1鼠单克隆抗体
  • 货号：
    CSB-MA406807
  • 规格：
    ￥1090
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded Human Skeletal Muscle Tissue using NBR1 Mouse mAb diluted at 1:200.
  • 其他：

产品详情

  • 产品描述：
    NBR1（Neighbor of BRCA1 gene 1）作为选择性自噬的核心接头蛋白，通过其UBAN结构域特异性识别泛素化底物，与p62协同调控错误折叠蛋白降解及细胞稳态，在肿瘤微环境调控、神经退行病理进程及代谢性疾病研究中备受关注。CUSABIO货号：CSB-MA406807 NBR1单克隆抗体基于重组蛋白免疫技术开发，经多物种验证可精准识别人类、小鼠、大鼠的NBR1蛋白靶点，适配ELISA定量检测与免疫组化（IHC）定位分析双重实验方案。该抗体凭借优异的抗原结合特异性，能清晰显示细胞内NBR1的亚定位分布特征，为探究自噬-溶酶体通路异常机制、构建癌症耐药性模型及神经退行性病变研究提供关键检测工具。研究者可将其应用于细胞系、动物组织切片等样本的蛋白互作分析、病理标志物定量评估以及自噬相关药物筛选实验，特别适用于研究p62/NBR1复合体在聚集体自噬（aggrephagy）中的协同作用机制，或探索线粒体自噬（mitophagy）过程中的分子调控网络。本产品严格质控确保实验重复性，是自噬研究、分子病理机制解析等基础科研领域的优选试剂。
  • Uniprot No.：
    Q14596
  • 基因名：
    NBR1
  • 别名：
    1A1 3B antibody; 1A13B antibody; B box protein antibody; Cell migration-inducing gene 19 protein antibody; KIAA0049 antibody; M17S2 antibody; Membrane component chromosome 17 surface marker 2 antibody; Membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) antibody; MIG 19 antibody; MIG19 antibody; Migration inducing protein 19 antibody; NBR 1 antibody; Nbr1 antibody; NBR1, autophagy cargo receptor antibody; NBR1_HUMAN antibody; Neighbor of BRCA1 gene 1 antibody; Neighbor of BRCA1 gene 1 protein antibody; Next to BRCA1 gene 1 protein antibody; Ovarian carcinoma antigen CA125 antibody; Protein 1A1-3B antibody
  • 宿主：
    Mouse
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Recombinant Protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • 克隆号：
    15E3
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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NBR1 antibodies

NBR1 Proteins

靶点详情

  • 功能：
    Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
  • 基因功能参考文献：
    1. NBR1 is not required for PARK2-dependent mitophagy. PMID: 26512954
    2. The NBR1 depletion impairs FA turnover and decreases targeting of autophagosomes to FAs, whereas ectopic expression of autophagy-competent, but not autophagy-defective, NBR1 enhances FA disassembly and reduces FA lifetime during migration. PMID: 26903539
    3. NBR1 positively correlates with adipose inflammation in human obese patients. PMID: 25043814
    4. Analysis of muscle biopsies of sporadic inclusion body myositis (sIBM) patients revealed a strong decrease of NBR1 phosphorylation in muscles of sIBM patients that directly correlated with the severity of protein aggregation. PMID: 24879152
    5. The C-terminal fragments of SQSTM1 and NBR1 exhibited a dominant-negative effect against native SQSTM1/NBR1, probably by competing for LC3 and ubiquitin chain binding. PMID: 24769734
    6. structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin PMID: 24692539
    7. results suggest that NBR1 is the specific autophagy receptor for pexophagy. PMID: 23239026
    8. These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in alpha-synucleinopathy. PMID: 22484440
    9. The structural ensemble representing each of the two sequential folding transition transition states of the PB1 domain of NBR1 has been calculated using experimental Phi values and biased molecular dynamics simulations. PMID: 21121670
    10. Autophagy-related NBR1 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases. PMID: 22728060
    11. Breast and ovarian cancer risk are high in Jewish women with BRCA1 genetic mutation. PMID: 22430266
    12. AtNBR1 is more similar to mammalian NBR1 than to p62 in domain architecture and amino acid sequence. PMID: 21606687
    13. Results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity of GABARAPL-1/NBR1-LIR complex. PMID: 21620860
    14. interacts with two proteins; fasciculation and elongation protein zeta-1 (FEZ1), a PKCzeta interacting protein, and calcium and integrin binding protein (CIB), also shows developmentally restricted expression in the neural tube PMID: 11856312
    15. NBR1 together with p62 promotes autophagic degradation of ubiquitinated targets and simultaneously regulates their aggregation when autophagy becomes limited. PMID: 19398892
    16. The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains. Nbr1 also binds to the autophagic effector protein LC3-A via a novel binding site. PMID: 19427866
    17. findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1. PMID: 19822672

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  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line.
  • 数据库链接：

    HGNC: 6746

    OMIM: 166945

    KEGG: hsa:4077

    STRING: 9606.ENSP00000343479

    UniGene: Hs.277721

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