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  4. LALBA Monoclonal Antibody

LALBA Monoclonal Antibody

说明书
  • 中文名称：
    LALBA鼠单克隆抗体
  • 货号：
    CSB-MA000242
  • 规格：
    ￥1090
  • 图片：
    • Western blot analysis of 1) Human Milk, 2) Milk, diluted at 1:3000.
  • 其他：

产品详情

  • 产品描述：
    CUSABIO货号：CSB-MA000242 LALBA单克隆抗体是针对α-乳白蛋白（LALBA）靶点研发的高特异性科研试剂，该靶点作为乳糖合成酶复合体的重要组分，在乳腺上皮细胞中特异性表达并参与乳糖生物合成调控，其表达水平与乳腺功能及乳腺癌相关机制研究密切相关。本产品采用杂交瘤技术制备，具有优异的人源特异性识别能力，经严格验证可稳定应用于酶联免疫吸附试验（ELISA）和蛋白质印迹（WB）两大主流检测平台，为研究者提供可靠的实验数据支持。该抗体适用于乳腺生物学研究、乳制品营养成分分析、乳腺癌发生发展机制探索等科研领域，尤其适合用于乳腺上皮细胞功能研究、乳糖代谢通路解析及肿瘤标志物筛选等实验场景。作为经过多批次质控验证的科研级抗体，CUSABIO货号：CSB-MA000242在实验中展现良好的批次稳定性和抗原结合活性，是开展LALBA蛋白功能研究、疾病分子机制探索的重要工具。
  • Uniprot No.：
    P00709
  • 基因名：
    LALBA
  • 别名：
    a-LACTA antibody; alfaLA antibody; Alpha-lactalbumin antibody; Lactalbumin alpha antibody; Lactose synthase B protein antibody; LALBA antibody; LALBA_HUMAN antibody; Lysozyme-like protein 7 antibody; LYZL7 antibody; MGC138521 antibody; MGC138523 antibody
  • 宿主：
    Mouse
  • 反应种属：
    Human
  • 免疫原：
    Synthetic Peptide
  • 免疫原种属：
    H
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 克隆号：
    21A10
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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LALBA Proteins

靶点详情

  • 功能：
    Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
  • 基因功能参考文献：
    1. Studies indicate that alpha-lactalbumin has two domains, a large alpha-helical domain and a small beta-sheet domain connected by a calcium binding loop. PMID: 27238572
    2. High molecular mass complexes are formed with alpha-lactalbumin and alphaB-crystallin, preventing the amorphous aggregation of alpha-lactalbumin. PMID: 23005341
    3. analysis of macromolecular crowding on the structural stability of human alpha-lactalbumin PMID: 22735492
    4. Data show that alpha-lactalbumin and CD14 form a complex in the gut which alters degradation of CD14, suggesting a mechanism by which this key LPS receptor may remain functional in the neonatal gut. PMID: 20717070
    5. The complexes formed by partially folded alpha-lactalbumin with oleic acid display selective apoptotic activity against tumor cells. PMID: 19968717
    6. comparison of the structural and stability properties of the isolated alpha-helical domain of lysozyme with that of alpha-lactalbumin PMID: 11718563
    7. pH-dependent stability of the alpha-lactalbumin molten globule state. PMID: 12833543
    8. Structural characterisation of the human alpha-lactalbumin molten globule at high temperature PMID: 12860137
    9. a functional Ca(2+)-binding site is not required for conversion of alpha-lactalbumin to the active complex or to cause cell death PMID: 14627739
    10. lipids are tissue-specific cofactors in alpha-lactalbumin protein folding PMID: 14627740
    11. NMR study of the conformation of HAMLET, the folding variant of human alpha-lactalbumin, complexed to oleic acid. PMID: 15075403
    12. The electrostatic nature of the alpha-lactalbumin (LA)-histone interaction justifies use of alpha-LA as a basis for design of antitumor agents, acting through disorganization of chromatin structure due to interaction between alpha-LA and histone. PMID: 15134431
    13. a folding variant of alpha-lactalbumin has a role in lactating mammary gland apoptosis PMID: 15141307
    14. the non-cooperative denaturation of the molten globule, alpha-lactalbumin secondary structure elements are stabilized by non-specific, non-native interactions PMID: 15558602
    15. Fold and topology of alpha-lactalbumin may be formed from degenerate groups of side chains. PMID: 15956205
    16. Local interactions as well as hydrophobic interactions formed in the molten globule state play an important role in organizing the structure in the transition state and in guiding the subsequent folding of alpha-lactalbumin. PMID: 16121399
    17. Results describe the reaction mechanism and formation of CIDNP (chemically induced dynamic nuclear polarization) in the photoreactions of the dye 2,2'-dipyridyl with non-native states of bovine and human alpha-lactalbumins in aqueous solution. PMID: 16851644
    18. alpha-lactalbumin molten globule has even more native-like character than suggested by studies conducted at higher temperature PMID: 18939797
    19. recombinant human alpha-LA was purified from transgenic milk and displayed physicochemical properties similar to its natural counterpart with respect to molecular weight, structure, and regulatory activity for beta-1,4-galactosyltransferase PMID: 19038921
    20. the structural preferences of the alpha-LA molten globule at pH 7 at the level of individual residues were investigated. PMID: 19766656
    21. hydrogen exchange behavior of variants using mass spectrometry PMID: 11518539

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Glycosyl hydrolase 22 family
  • 组织特异性：
    Mammary gland specific. Secreted in milk.
  • 数据库链接：

    HGNC: 6480

    OMIM: 149750

    KEGG: hsa:3906

    STRING: 9606.ENSP00000301046

    UniGene: Hs.72938

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