Your Good Partner in Biology Research

中文简体

CSF2｜ CTLA4｜ DLL3｜ EGFR｜ IL4｜ IL4R｜ LAG3｜ MSTN｜ NECTIN4｜ NT5E｜ SEZ6｜ TM4SF1｜ TNFSF13｜ TPO

  1. Home
  2. 抗体
  3. 单克隆抗体
  4. Histone H2B Monoclonal Antibody

Histone H2B Monoclonal Antibody

说明书
  • 中文名称：
    组蛋白H2B鼠单克隆抗体
  • 货号：
    CSB-MA000324
  • 规格：
    ￥1090
  • 图片：
    • Western blot analysis of 1) Hela, 2) 3T3, 3) Raw264.7, 4) Rat Brain, 5) Rat Kidney, diluted at 1:2000.
  • 其他：

产品详情

  • 产品描述：
    CUSABIO货号：CSB-MA000324组蛋白H2B单克隆抗体是专为生命科学研究设计的核心实验试剂，靶向高度保守的核小体结构蛋白Histone H2B。作为染色质组装的关键组分，H2B通过与H2A形成异源二聚体参与DNA包装和表观遗传调控，在细胞周期进程、DNA修复及基因表达中发挥重要作用。该抗体经严格验证适用于人、小鼠、大鼠三大模式生物的实验体系，在Western Blot实验中可清晰识别约14kDa的目标条带，同时兼容ELISA检测平台，为研究者提供可靠的蛋白识别工具。在表观遗传调控机制研究、干细胞分化模型构建、肿瘤微环境分析等前沿领域具有重要应用价值，尤其适用于染色质动态变化观察、组蛋白修饰互作研究及表观遗传药物开发等科研场景。其高特异性和批次稳定性已通过多物种组织裂解液测试验证，是探索基因表达调控网络和疾病分子机制的首选抗体试剂。
  • Uniprot No.：
    P33778
  • 基因名：
    HIST1H2BB
  • 别名：
    HIST1H2BB antibody; H2BFFHistone H2B type 1-B antibody; Histone H2B.1 antibody; Histone H2B.f antibody; H2B/f antibody
  • 宿主：
    Mouse
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原种属：
    H, M, R
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 克隆号：
    24D11
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

相关产品

HIST1H2BB antibodies

HIST1H2BB Proteins

靶点详情

  • 功能：
    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • 基因功能参考文献：
    1. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants has been uncovered. PMID: 29643390
    2. RNF20 and H2Bub1 promotes chronic colonic inflammation and inflammation-associated colorectal cancer in mice and humans, partly by augmenting NF-kappaB activity and attenuating the antitumoral T cell response. PMID: 26854224
    3. RNF20-mediated H2B ubiquitination at DSBs plays a critical role in HRR through chromatin remodeling PMID: 21362548
  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Histone H2B family
  • 数据库链接：

    HGNC: 4751

    OMIM: 602803

    KEGG: hsa:3018

    STRING: 9606.ENSP00000350580

    UniGene: Hs.553494

Most popular with customers

产品中心
特别关注


X
九游平台-九游(中国) | 米兰体育-米兰体育（中国） | 开云手机在线登陆入口 | 江南官方体育网页版 | 开云网页版 | 开云官方在线入口 | 开云电子体育 | 开云官方链接 | 江南网页版页面登录 |