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GBP2 Monoclonal Antibody

说明书
  • 中文名称：
    GBP2鼠单克隆抗体
  • 货号：
    CSB-MA009298A0m
  • 规格：
    ￥1320
  • 图片：
    • Immunofluorescence staining of U87 cells with CSB-MA009298A0m at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG (H+L).
    • IHC image of CSB-MA009298A0m diluted at 1:100 and staining in paraffin-embedded human colon tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品描述：
    CUSABIO货号：CSB-MA009298A0m人源GBP2单克隆抗体是针对干扰素诱导蛋白GBP2（Guanylate-binding protein 2）研发的高特异性科研试剂。GBP2作为鸟苷酸结合蛋白家族成员，在先天免疫应答中发挥重要作用，参与宿主防御病毒与胞内病原体感染过程，其表达受干扰素-γ信号通路调控。该单克隆抗体采用杂交瘤技术制备，适用于ELISA酶联免疫吸附、IHC免疫组化及IF免疫荧光三大实验平台，能够精准识别人类GBP2蛋白的特定表位，为研究宿主免疫反应机制、病原体感染调控网络及炎症性疾病模型构建提供可靠工具。在肿瘤微环境分析、自身免疫疾病机制探索及抗病毒药物研发等科研领域，本产品可有效应用于细胞定位观察、组织切片染色及蛋白质定量检测等实验场景。严谨的质量控制体系确保抗体批次稳定性，满足各类复杂实验设计需求，是免疫学、细胞生物学及感染性疾病研究领域的优选试剂。
  • 产品名称：
    Mouse anti-Homo sapiens (Human) GBP2 Monoclonal Antibody antibody
  • Uniprot No.：
    P32456
  • 基因名：
    GBP2
  • 别名：
    GBP2Guanylate-binding protein 2 antibody; EC 3.6.5.- antibody; GTP-binding protein 2 antibody; GBP-2 antibody; HuGBP-2 antibody; Guanine nucleotide-binding protein 2 antibody; Interferon-induced guanylate-binding protein 2 antibody
  • 宿主：
    Mouse
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Guanylate-binding protein 2 protein (100-259AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal Antibody
  • 抗体亚型：
    IgG2b
  • 纯化方式：
    >95%, Protein A purified
  • 克隆号：
    1H6F9
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200;IHC:1:50-1:200
  • Protocols：
    ELISA Protocol
    Immunofluorescence (IF) Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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GBP2 antibodies

GBP2 Proteins

靶点详情

  • 功能：
    Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
  • 基因功能参考文献：
    1. Study presents the first demonstration that GBP2 inhibits mitochondrial fission and cell metastasis in breast cancer cells both in vitro and in vivo. PMID: 29072687
    2. Low GBP2 expression is associated with metastasis in breast cancer. PMID: 23001506
    3. Downregulation of MIR-433 is associated with myeloproliferative neoplasms. PMID: 22864358
    4. The in vivo localization of GBP-2 at cellular membranes is regulated by isoprenylation and dimerization. PMID: 21151871
    5. Guanylate-binding protein 2 mRNA in peripheral blood leukocytes may have a role in acute cellular rejection after liver transplantation PMID: 19912588
    6. Sky1p utilizes the same docking groove to bind yeast SR-like protein Gbp2p and phosphorylates all three serines present in a contiguous RS dipeptide stretch PMID: 17517895
    7. GBP-2 is regulated by p53 and may have a role in esophageal squamous cell carcinomas PMID: 19003964

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus membrane. Membrane; Lipid-anchor.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3-type GTPase family, GB1 subfamily
  • 数据库链接：

    HGNC: 4183

    OMIM: 600412

    KEGG: hsa:2634

    STRING: 9606.ENSP00000359497

    UniGene: Hs.386567

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