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  4. FILIP1L Monoclonal Antibody

FILIP1L Monoclonal Antibody

说明书
  • 中文名称：
    FILIP1L鼠单克隆抗体
  • 货号：
    CSB-MA679703A0m
  • 规格：
    ￥1320
  • 图片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate
      All lanes: FILIP1L antibody at 1:1000
      Secondary
      Goat polyclonal to mouse IgG at 1/50000 dilution
      Predicted band size: 102 kDa
      Observed band size: 29, 80, 102, 130 KDa
      Exposure time：5min
  • 其他：

产品详情

  • 产品描述：
    FILIP1L单克隆抗体（CUSABIO货号：CSB-MA679703A0m）是针对人源FILIP1L蛋白研发的高特异性科研试剂，适用于探索细胞骨架动态调控及肿瘤发生机制等领域的研究。FILIP1L（Filamin A相互作用蛋白1样）作为调控肌动蛋白结合的关键分子，在细胞迁移、极性建立及信号转导过程中发挥重要作用，其异常表达与多种恶性肿瘤的侵袭转移密切相关。本产品经严格验证可同时满足ELISA和Western Blot两种实验需求，具有优异的人源样本反应特异性，能够精准识别内源性FILIP1L蛋白的表达水平。研究人员可借助该抗体在体外模型中解析肿瘤细胞迁移机制，或结合组织样本分析FILIP1L在癌症病理进程中的调控网络，为开发靶向细胞骨架的新型抗肿瘤策略提供可靠工具。该FILIP1L抗体采用稳定生产工艺，批次间一致性经过多轮验证，确保在蛋白印迹和酶联免疫实验中呈现清晰的检测信号，是研究细胞运动性、肿瘤微环境及转移机制的重要试剂选择。
  • 产品名称：
    Mouse anti-Homo sapiens (Human) FILIP1L Monoclonal Antibody antibody
  • Uniprot No.：
    Q4L180
  • 基因名：
    FILIP1L
  • 别名：
    130 kDa GPBP-interacting protein antibody; 90 kDa GPBP-interacting protein antibody; COL4A3BPIP antibody; DOC-1 antibody; DOC1 antibody; Downregulated in ovarian cancer 1 81 kDa isoform antibody; FIL1L_HUMAN antibody; Filamin A-interacting protein 1-like antibody; FILIP1L antibody; GIP130 antibody; GIP130a antibody; GIP130b antibody; GIP130c antibody; GIP90 antibody; GPBP interacting protein 90 antibody; Protein down-regulated in ovarian cancer 1 antibody
  • 宿主：
    Mouse
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Filamin A-interacting protein 1-like protein (1-200AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal Antibody
  • 抗体亚型：
    IgG1
  • 纯化方式：
    >95%, Protein G purified
  • 克隆号：
    4H7G5
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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FILIP1L antibodies

FILIP1L Proteins

靶点详情

  • 功能：
    Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.
  • 基因功能参考文献：
    1. FILIP1L inhibits progression in colorectal cancer by inhibiting tumor cell proliferation and angiogenesis. PMID: 27750216
    2. Studies have shown that FILIP1L expression is related with inhibition of metastases and chemoresistance of ovarian neoplasm, which is associated with downregulation of EMT through beta-catenin degradation. FILIP1L expression correlates with significantly improved overall survival. PMID: 27776341
    3. these findings suggest that FILIP1L reduces beta-catenin levels, which may lead to the transcriptional downregulation of WNT target genes such as MMPs, resulting in inhibition of metastasis PMID: 24327474
    4. down-regulation of FILIP1L associated with DNA methylation is related with the invasive phenotype in various cancers. PMID: 24340050
    5. these findings suggest that downregulation of FILIP1L associated with DNA methylation is related with the invasive phenotype in ovarian cancer and that modulation of FILIP1L expression has the potential to be a target for ovarian cancer therapy. PMID: 21693594
    6. a novel function for FILIP-1L and a pathway for Hsf1 degradation through the ubiquitin-proteasome system. PMID: 21784850
    7. DOC1 might play a role in mediating some of the effects of EMAP-II on endothelial cells PMID: 15935955

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  • 亚细胞定位：
    Cytoplasm. Membrane. Nucleus.
  • 蛋白家族：
    FILIP1 family
  • 组织特异性：
    Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. D
  • 数据库链接：

    HGNC: 24589

    OMIM: 612993

    KEGG: hsa:11259

    STRING: 9606.ENSP00000346560

    UniGene: Hs.104672

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