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  4. COX4I1 Monoclonal Antibody

COX4I1 Monoclonal Antibody

文献引用 (1) 说明书
  • 中文名称：
    COX4I1鼠单克隆抗体
  • 货号：
    CSB-MA000188
  • 规格：
    ￥1090
  • 图片：
    • Western blot analysis of Hela, diluted at 1) 1:2000 2) 1:5000
  • 其他：

产品详情

  • 产品描述：
    【COX4I1单克隆抗体CUSABIO货号：CSB-MA000188】该产品是针对细胞色素c氧化酶亚基4I1（COX4I1）研发的高特异性单克隆抗体，适用于人、小鼠、大鼠等哺乳动物样本的ELISA和Western Blot检测。COX4I1作为线粒体内膜呼吸链复合体IV的核心组分，在能量代谢和氧化磷酸化过程中发挥关键作用，其表达水平与细胞能量稳态、肿瘤代谢重编程及神经退行性疾病密切相关。本产品经严格验证可特异性识别天然构象的COX4I1蛋白，具有高亲和力与批次稳定性，适用于线粒体功能研究、代谢相关疾病机制探索、肿瘤微环境分析等科研领域。在Western Blot实验中可清晰检测约17kDa的目标条带，配套提供优化实验方案助力研究者快速开展能量代谢调控、衰老相关疾病模型构建等前沿课题。该抗体作为线粒体研究的重要工具，为探索心血管疾病、阿尔茨海默症等病理过程中能量代谢异常机制提供可靠支持，满足分子生物学、细胞生物学等多学科研究需求。
  • Uniprot No.：
    P13073
  • 基因名：
    COX4I1
  • 别名：
    AL024441 antibody; COX 4 antibody; COX IV 1 antibody; COX IV antibody; COX IV-1 antibody; Cox4 antibody; COX41_HUMAN antibody; Cox4a antibody; COX4B antibody; COX4I1 antibody; COX4I2 antibody; COX4L2 antibody; COXIV antibody; Cytochrome c oxidase polypeptide IV antibody; Cytochrome c oxidase subunit 4 isoform 1 mitochondrial antibody; Cytochrome c oxidase subunit 4 isoform 1, mitochondrial antibody; Cytochrome C Oxidase subunit IV antibody; Cytochrome c oxidase subunit IV isoform 1 antibody; Cytochrome c oxidase subunit IV isoform 2 (lung) antibody; Cytochrome c oxydase subunit 4 antibody; dJ857M17.2 antibody; MGC105470 antibody; MGC72016 antibody
  • 宿主：
    Mouse
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Recombinant Protein
  • 免疫原种属：
    H, R, M
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 克隆号：
    30H2
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文献

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COX4I1 antibodies

COX4I1 Proteins

靶点详情

  • 功能：
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能参考文献：
    1. In case of myocardial insufficiency and dilated cardiomyopathy, decreased expression of COX 4 results in an impaired CytOx activity. Higher enzymatic activity but equal oxygen consumption contribute to the pathophysiology of the myocardial insufficiency and appears as an indicator of oxidative stress. This kind of dysregulation should be in the focus for the development of diagnostic and therapy procedures PMID: 30223867
    2. COX4I1 variant K101N was identified in a patient with short stature, poor weight gain and increased chromosomal breaks, simulating Fanconi anemia. PMID: 28766551
    3. This cohort study showed that the COX411 gene was down regulation between patients with idiopathic Parkinson disease and controls PMID: 28916538
    4. We provide evidence that COX4-1 controls BMI1 expression via a redox mechanism PMID: 25726526
    5. COXIV mRNA (1.6 fold; P<0.01) and COXIV protein expression (1.5 fold; P<0.05) were increased by training but COXIV protein expression was decreased (20%; P<0.01) by acute exercise pre- and post-training. PMID: 23285255
    6. COX activity (electron transport complex IV) is reduced by 29% in maternal history of Alzheimer's disease compared to normal controls, and by 30% compared to paternal history of Alzheimer's disease. PMID: 21841246
    7. Studies suggest a model that links cell signaling with the phosphorylation state of Cytochrome c (Cytc) and cytochrome c oxidase (COX). PMID: 21771582
    8. Studies suggest that the main function of nuclear encoded subunits of cytochrome c oxidase appears to be "only" to control the activity of the mitochondrial subunits. PMID: 21802404
    9. Studies indicate that the mechanism for proton pumping in cytochrome c oxidase is based on an electrostatic analysis of a kinetic experiment for the O to E transition. PMID: 21978537
    10. Studies indicate that nitric oxide (NO) inhibition of cytochrome c oxidase (CcOX) is rapid and reversible and may occur in competition with oxygen. PMID: 21939634
    11. Studies indicate that the cytochrome oxidase enzyme-substrate (ES) Michaelis complex of cell respiration, the dioxygen adduct of heme a(3), which he termed Compound A. PMID: 22079200
    12. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4 PMID: 20307258
    13. Data found that subunits Cox6a, Cox6b and Cox7a assembled into pre-existing complex IV, while Cox4-1 and Cox6c subunits assembled into subcomplexes that may represent rate-limiting intermediates. PMID: 19843159
    14. study points to a role for surfeit 1(SURF1) in promoting the association of cytochrome c oxidase II with the cytochrome c oxidase I.cytochrome c oxidase subunit 4.cytochrome c oxidase subunit 5A subassembly PMID: 14607829
    15. Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 reciprocally regulates COX4 subunit expression by activating transcription of the genes encoding COX4-2 and LON, a mitochondrial protease that is required for COX4-1 degradation. PMID: 17418790

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  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    Cytochrome c oxidase IV family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 2265

    OMIM: 123864

    KEGG: hsa:1327

    STRING: 9606.ENSP00000253452

    UniGene: Hs.433419

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