Rat anti-Mullerian hormone (AMH) ELISA kit

Rat anti-Mullerian hormone (AMH) ELISA kit

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中文名称：

大鼠缪勒管抑制物质/抗缪勒管激素(AMH)酶联免疫试剂盒
货号：

CSB-E11162r
规格：

96T/48T
价格：

￥3600/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

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产品描述：

本产品是一款专为大鼠样本设计的缪勒管抑制物质/抗缪勒管激素（AMH）定量检测试剂盒，采用竞争性酶联免疫吸附法（ELISA）原理，能够精准测定血清、血浆及组织匀浆中的AMH含量，灵敏度可达0.2 ng/mL，检测上限为15 ng/mL。AMH作为调控性腺发育的关键因子，在大鼠生殖系统发育、卵泡形成及精子发生等生理过程中发挥重要作用，其水平变化与性腺功能状态密切相关。该试剂盒通过预包被特异性抗体，利用生物素标记抗原与样本中AMH竞争结合的特性实现定量分析，操作流程标准化，具备良好的重复性和准确性，配套提供标准品及实验所需试剂。适用于生殖生物学、内分泌学等领域的科学研究，可用于探索性腺发育机制、评估生殖相关疾病模型中的激素水平动态变化，或用于药物干预实验中对AMH表达调控的效应分析，为深入解析大鼠生殖系统功能提供可靠工具。
别名：

Amh ELISA Kit; Muellerian-inhibiting factor ELISA Kit; Anti-Muellerian hormone ELISA Kit; AMH ELISA Kit; Muellerian-inhibiting substance ELISA Kit; MIS ELISA Kit
缩写：

AMH
Uniprot No.：

P49000
种属：

Rattus norvegicus (Rat)
样本类型：

serum, plasma, tissue homogenates
检测范围：

0.2 ng/mL-15 ng/mL
灵敏度：

0.1 ng/mL
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Signal Transduction
测定原理：

quantitative
测定方法：

Competitive

精密度：

标准曲线：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ng/ml

OD1

OD2

Average

2.179

2.234

2.207

0.2

1.752

1.667

1.710

0.6

1.411

1.428

1.420

1.75

0.823

0.829

0.826

0.482

0.501

0.491

0.264

0.253

0.259

数据处理：

ELISA操作视频及标曲绘制软件下载
货期：

3-5 working days

Huyang Yangkun formula regulates the mitochondria pathway of ovarian granulosa cell apoptosis through FTO/ m6A-P53 pathway Y Li, L Wang, J Liu, G Nie, H Yang,Frontiers in Pharmacology,2024
MSCs–derived EVs protect against chemotherapy-induced ovarian toxicity: role of PI3K/AKT/mTOR axis NM Elsherbiny, MS Abdel-Maksoud, K Prabahar,Journal of Ovarian Research,2024
Negative effects of ethanol on ovarian reserve and endometrium thickness: An animal study E Karaman, ME Ayağ,Turk J Obstet Gynecol,2024
Novel Molecular Mechanisms Underlying the Ameliorative Effect of Platelet-Rich Plasma against Electron Radiation-Induced Premature Ovarian Failure G Demyashkin, M Vadyukhin, Z Murtazalieva,International Journal of Molecular Sciences,2024
Sildenafil as a Salvage Treatment for Ovarian Torsion: A Rat Model DA Yaginc,/,2023
Energy Drinks May Affect the Ovarium MM Ismatova,/,2023
Chronic Fluoride Exposure Induces Ovarian Dysfunction and Potential Association with Premature Ovarian Failure in Female Rats X Tang,Biological trace element research,2023
Participación del factor inhibitorio de leucemia en los niveles de acetilcolina y en la foliculogénesis ovárica en rata SI Peña Díaz,/,2023
Zuogui pills maintain the stemness of oogonial stem cells and alleviate cyclophosphamide-induced ovarian aging through Notch signaling pathway L Zeng,Phytomedicine,2023
Altered m6A modification is involved YAP-mediated apoptosis response in 4-vinylcyclohexene diepoxide induced ovotoxicity Y Li,Ecotoxicology and environmental safety,2023
Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats A Al-Shahat,Pharmaceutics,2022
Mechanistic insights into the protective role of eugenol against stress-induced reproductive dysfunction in female rat model H Helmy,Chemico-biological interactions,2022
miR-20a Overexpression in Adipose-Derived Mesenchymal Stem Cells Promotes Therapeutic Efficacy in Murine Lupus Nephritis by Regulating Autophagy S Wei,EBioMedicine,2021
Promising anti- cervical carcinoma and inflammatory agent, Resveratrol targets poly (ADP-ribose) polymerase 1 (PARP-1) induced premature ovarian failure with a potent enzymatic modulatory activity H Alharbi,Journal of Reproductive Immunology,2021
Impact of Curcumin on Ovarian Reserve After Tubal Ligation: an Experimental Study GD Isgoren,Reproductive Sciences,2021
Effects of Coenzyme Q10 on Ovarian Surface Epithelium-derived Ovarian Stem Cells and Ovarian Function in 4-vinylcyclohexene Diepoxide-induced Ovarian Failure Mice Hyun Joo Lee,Research Square,2021
Phytoestrogen genistein hinders ovarian oxidative damage and apoptotic cell death-induced by ionizing radiation: co-operative role of ER-β, TGF-β, and FOXL-2 YH Haddad,Scientific Reports,2020
CUMS Promotes the Development of Premature Ovarian Insufficiency Mediated by Nerve Growth Factor and Its Receptor in Rats X Fu,BioMed Research International,2020
Continuous Light-Induced PCOS-Like Changes in Reproduction, Metabolism, and Gut Microbiota in Sprague-Dawley Rats W Chu,Front. Microbiol,2020
FSH/AMH Ratio and Adipocyte Size are Linked to Ovarian Dysfunction Roberts JA,Endocr. Res,2020
The regulation of the follicular synchronization and sensitivity of rats with PCOS by AMH during prolonged pituitary downregulation Huang J, et al,Gene,2019
Prenatal ethanol exposure induces susceptibility to premature ovarian insufficiency Ni Y, et al,Journal of Endocrinology,2019
Mechanistic perspective of protective effects of resveratrol against cisplatin-induced ovarian injury in rats: emphasis on anti-inflammatory and anti-apoptotic effects Said RS,Naunyn-Schmiedeberg\'s Archives of Pharmacology,2019
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Umbilical Cord Mesenchymal Stem Cell Transplantation Prevents Chemotherapy-Induced Ovarian Failure via the NGF/TrkA Pathway in Rats Qun Zheng,BioMed Research International,2019
Effects of VEGF + Mesenchymal Stem Cells and Platelet-Rich Plasma on Inbred Rat Ovarian Functions in Cyclophosphamide-Induced Premature Ovarian Insufficiency Model Vural B,Stem Cell Reviews and Reports,2019
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Assaying Reproductive Capacity in Female Rodents Aiken CE, et al,Methods in Molecular Biology,2018
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High-Fat, High-Sugar Diet Disrupts the Pre-ovulatory Hormone Surge and Induces Cystic Ovaries in Cycling Female Rats Katrina M Volk.et al,Journal of the Endocrine Society,2017
Antimullerian hormone and its receptor gene expression in prenatally androgenized female rats. Daneshian Z.et al,Int J Endocrinol Metab.,2015
Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics. An D.et al,Sci Rep.,2015
The Effects of Diabetes Mellitus on Ovarian Injury and Reserve: An Experimental Study Nayki U. et al,Gynecol Obstet Invest,2015
Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly(ADP-ribose) polymerase 1 (PARP-1) Riham Soliman Said.et al,Biochemical Pharmacology,2016
Kisspeptin is involved in ovarian follicular development during aging in rats Fernandois DD. et al,J Endocrinol,2015
Exposure of Female Rats to an Environmentally-Relevant Mixture of Brominated Flame Retardants Targets the Ovary, Affecting Folliculogenesis and Steroidogenesis Lef猫vre PL. et al,Biol Reprod,2015
Evaluation of the effects of fulvestrant and micronized progesterone on the post-operative adhesion formation and ovarian reserve in rat model with ? Oner G. et al,Gynecol Endocrinol,2015
Suboptimal nutrition in utero causes DNA damage and accelerated aging of the female reproductive tract Aiken CE et al,FASEB J,2013
The Biochemical and Histologic Effects of Adnexal Torsion and Early Surgical Intervention to Unwind Detorsion on Ovarian Reserve An Experimental Study Ozler A et al,Reprod Sci.,2013

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最新研究进展：

AMH是一种由生殖细胞产生的生长因子，主要参与了性腺的发育和生殖调节。最新研究表明，AMH在女性中发挥着重要的作用，如参与卵巢生长和发育、卵泡发育和成熟、排卵和孕产等过程。此外，AMH在生殖医学中也被广泛应用于卵巢储备功能评估和IVF治疗等方面。近年来，一些新型AMH检测技术的研究也为AMH在临床上的应用提供了更加准确和可靠的方法。
功能：

This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
基因功能参考文献：
1. The study uncovers a new role for AMH in regulating gonadotrope function and suggests that AMH participates in the postnatal elevation of FSH secretion in females. PMID: 27030385
2. AMH increases GnRH-dependent LH pulsatility and secretion, supporting a central action of AMH on GnRH neurons. PMID: 26753790
3. Resveratrol reduced antimullerian hormone levels in rat model of polycystic ovary syndrome. PMID: 25667201
4. AMH is the first hormone/protein shown to have an inhibitory action on primordial follicle assembly. PMID: 21637711
5. In ovaries from adult cycling rats AMH protein is localized in large primary and secondary follicles and not in primordial or small primary follicles, with its highest expression in the largest preantral follicles. PMID: 20816688
6. Mullerian inhibiting substance regulates gonadotropin gene expression PMID: 12878721
7. MIS inhibits regeneration of Leydig cells in ethylene dimethanesulfonate-treated rats by enhancing apoptotic cell death as well as by decreasing proliferative capacity. PMID: 14585814
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亚细胞定位：

Secreted.
蛋白家族：

TGF-beta family
数据库链接：

KEGG: rno:25378

STRING: 10116.ENSRNOP00000026220

UniGene: Rn.19121

Intra-assay Precision (Precision within an assay): CV%<15%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<15%

Three samples of known concentration were tested in twenty assays to assess.