Rat Tryptophan Hydroxylase (TPH) ELISA Kit

1. Ursolic acid derivatives targeted to tryptophan hydroxylase 1 prevented bone loss by suppressing serotonin biosynthesis without estrogenic side-effects in ovariectomized rats. PMID: 25930119
2. there exists possible interrelation between tyrosine hydroxylase and TPH gene expression and epigenetic histone acetylation in chronic unpredictable stress-induced depressive rats, which at least partly contributes to the etiology of depression. PMID: 24495952
3. An increased expression of TPH1 in the dorsal raphe nucleus may be the primary mechanism to explain the chronic increase in the brain synthesis of 5-HT in these in utero malnourished rats. PMID: 22819790
4. Transfection of VMAT-1 and TPH-1 induced vesicular storage of serotonin which is triggered release upon cooling and has protective effects against hypothermia. PMID: 22253933
5. An adjacent GC-rich cis -acting sequence cooperates with the inverted CCAAT box for full activation of basal transcription; both elements are essential for full cAMP response. In pinealocytes, NF-Y and Sp1 bind the inverted CCAAT box and GC-rich-region PMID: 12065627
6. regulation of rat tryptophan hydroxylase gene expression by stress involves 5' untranslated region PMID: 12153488
7. TPH1 mRNA expression was 105-fold more abundant in rat pineal than TPH2; TPH2 expression within the gland showed no significant variation with time of day and was very low. PMID: 12911638
8. This study reveals adrenal glucocorticoid-independent induction of tryptophan hydroxylase gene expression in raphe nuclei in response to immobilization stress. PMID: 14744469
9. TPH2 mRNA is expressed in raphe, in a pattern overlapping the histologically defined raphe nuclei. In sharp contrast, TPH1 (the previously known TPH) is expressed predominantly in pineal gland. PMID: 14960297
10. Tph1 and Tph2 transcripts showed robust diurnal rhythms of abundance, with highest levels at night. PMID: 15194882
11. Results show that the synthesis of 5-hydroxytryptamine and the expression of tryptophan hydroxylase in the dorsal raphe of rat offspring were suppressed by maternal ethanol intake. PMID: 16198203
12. TPH1 mRNA is 2.5-fold upregulated by the stress in dorsal raphe nucleus but not in pineal gland. PMID: 18197473
13. Data showed that calcium influx blockaded by nifedipine caused a decrease in tryptophan hydroxylase activity. PMID: 18221757
14. mRNA for TPH-1 was present in peripheral arteries, with low levels of TPH protein and TPH activity PMID: 18414394
15. data support the model that increased nocturnal 5-HT synthesis in the pineal gland is mediated by the phosphorylation of TPH1 at the serine 58, which elevates the TPH1 protein content and activity at night PMID: 18705647

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KEGG: rno:24848

STRING: 10116.ENSRNOP00000052959

UniGene: Rn.94788