Rat Thioredoxin,Trx ELISA Kit

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.

1. A delay in tumor formation and a lower cancerization rate was observed following the inhibition of Trx-1 with an irreversible inhibitor in the rat squamous cell carcinoma model. PMID: 29328386
2. Data suggest that thioredoxin-1 (Trx1) modulates activity of soluble nitric oxide-sensitive guanylyl cyclase (GC1, subunits alpha and beta) through an association between Trx1 and GC1 via a mixed disulfide; Trx1 protects GC1 from desensitization. These studies were conducted, in part, using rat neonatal cardiomyocytes in primary culture. PMID: 28659344
3. Trx1 exerts its neuroprotective effects by preventing oxidative stress in astrocytes via maintaining Prdx expression. PMID: 26846911
4. Ginsenoside Rb1 shows a potent anti-oxidative effect on cultured PC12 cells by inducing Trx-1 expression. PMID: 26346161
5. expression increased in cold adaptation PMID: 26327811
6. Results suggest that Trx1 siRNA increases apoptotic stress-induced ASK1 activation and this represents further evidence that Trx1 is an endogenous anti-apoptotic molecule that diminishes focal cerebral ischemia/reperfusion injury PMID: 25541364
7. both type 1 and type 2 diabetic rats demonstrated a significant increase in TxnIP mRNA and reduction in thioredoxin activity when compared to non-diabetic animals. PMID: 24925443
8. Reduced form of Trx is required for cerebellar granule cell survival. PMID: 25055978
9. Mycophenolic acid reduces the expression of Trx1 at the protein and gene levels, leading to the apoptosis of insulin-secreting cells via the MKK4/7-JNK pathway. PMID: 23846223
10. Data indicate that Trx-1 is a therapeutic candidate for protecting against formaldehyde-induced neurotoxicity. PMID: 22342837
11. the wave-like oscillations of Trx-1 expression during hypobaric hypoxia preconditioning was described in hypothalamus. PMID: 22165200
12. Data suggest that Trx1 decreases in optic nerves and isolated retinal ganglion cells (RGC) after exposure to tumor necrosis factor-alpha in models of optic nerve degeneration with subsequent loss of RGC; 17beta-estradiol regulates expression of Trx1. PMID: 21586560
13. Data provide implication of the Trx1/Txnip system in hepatic I/R injuries. PMID: 20709139
14. respiration- and thioredoxin-dependent ROS removal as a potentially important mitochondrial function that may contribute to physiological and pathological processes in the brain PMID: 20558743
15. Thioredoxin may mediate the neuroprotection conferred by estradiol against iron-induced brain injury in vivo. PMID: 19940280
16. vitamin D(3)-up-regulated protein-1/thioredoxin axis has an important role in the preservation of cellular viability PMID: 12011048
17. Activation of thioredoxin participates in the development of pressure-overload cardiac hypertrophy, demonstrating the dual function of thioredoxin as both an antioxidant and a signaling protein. PMID: 15123525
18. reduced thioredoxin activity through interaction with Txnip is an important mechanism for vascular oxidative stress in diabetes mellitus PMID: 15128745
19. AlphaAR-stimulated hypertrophic signaling in adult rat ventricular myocytes is mediated via a TRX1-sensitive posttranslational oxidative modification of thiols on Ras. PMID: 15723974
20. during thioredoxin-dependent enzymatic activation of mercaptopyruvate sulfurtransferase, an intersubunit disulfide bond serves as a redox switch for activation PMID: 17130129
21. Our findings indicate that cholestasis is associated with significant mutual and interrelated changes between circulating and hepatic thioredoxin and nitrosothiols. PMID: 17256724
22. AngII induces thioredoxin in neuronal cultures. Thioredoxin then negatively regulates AngII stimulated neuronal activity via modulation of delayed rectifier K+ currents. PMID: 17360810
23. Diabetes impairs exercise training-associated thioredoxin response and glutathione status in rat brain. PMID: 19074570

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Nucleus. Cytoplasm. Secreted.

Thioredoxin family

KEGG: rno:116484

STRING: 10116.ENSRNOP00000016447

UniGene: Rn.29777