Rat Neprilysin(MME) ELISA kit

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of the atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.

1. hypoxia increased the expression of platelet-derived growth factor (PDGF) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells. PMID: 27373199
2. The data obtained suggest that the increase of caspase-3 enzyme activity could affect NEP expression via proteolytic degradation of its transcription factor AICD PMID: 26983277
3. the increased expression of NPR-C (r=-0.943 and -0.837 for mRNA and protein respectively, p<0.05) and NEP (r=-0.687 and -0.823 for mRNA and protein respectively, p<0.05) were accompanied by a signi fi cant decline in CNP. PMID: 24189506
4. Data suggest that the brain expression of neprilysin may promote amyloid beta-protein (Abeta)deposition in patients with Alzheimer's disease (AD). PMID: 24508800
5. These results suggested that ketamine suppresses the Abeta degradation of NEP by reducing p38 MAPK-mediated pathway activity. PMID: 23624023
6. Naoerkang can increase the expression of NEP in hippocampal tissues of AD rats so as to reduce the quantity of AAbeta(1-42). PMID: 20141738
7. The three Abeta-degrading enzymes were damaged to different extents in the brain of diabetic rats, and impairment of ECE-1 and IDE partly contributed to the elevated Abeta(1-40) levels in brain of diabetic rats. PMID: 20414044
8. Androgen regulation of amyloid beta (Abeta)protein involves an androgen receptor-dependent mechanism requiring up-regulation of Abeta catabolizing enzyme neprilysin. PMID: 18346198
9. Ovariectomy increases BACE1 expression and decreases neprilysin expression in hippocampus. PMID: 20137687
10. Intracardiac expression of neutral endopeptidase PMID: 12030369
11. in spontaneously hypertensive rats, the local concentration and action of adrenomedullin in the tissues may be differentially regulated by NEP. PMID: 15005274
12. Neutral endopeptidase inactivity induces an exaggerated neurogenic inflammation mediated by neurokinin-1 receptor, which may lead to edema in pulmonary alveoli. PMID: 15194566
13. Report that CGS 35601 and its orally active prodrug CGS 37808 are triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme. PMID: 15838282
14. Examine the effect of triple vasopeptidase inhibition of angiotensin-converting enzyme/neutral endopeptidase/endothelin-converting enzyme activities on the hemodynamic profile of spontaneously hypertensive rats. PMID: 15838331
15. neutral endopeptidase activity is decreased by ascorbic acid in cultured osteoblastic cells PMID: 15908023
16. The promoter of NEP is frequently methylated in hepatocellular carcinoma in contrast to its unmethylated status in normal liver. PMID: 16827801
17. These results demonstrate that expression of neprilysin and aminopeptidase N can be regulated when peptide neurons are activated and, that regulation is enzyme-, region-, and stage-specific. PMID: 17952634
18. NEP inhibition potentiates substance P-mediated neutrophil oxygen radical production and may promote other inflammatory activities during Mg-deficiency PMID: 18607539
19. chromatin immunoprecipitation analysis also reveals amyloid precursor protein binding to the NEP promoter in rat primary neurons but not in HUVEC cells PMID: 19057576
20. results show that acute immobilization stress affects differentially enkephalinase and oxytocinase activities depending on the fraction and brain region analyzed PMID: 19468242

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Cell membrane; Single-pass type II membrane protein.

Peptidase M13 family

KEGG: rno:24590

STRING: 10116.ENSRNOP00000044578

UniGene: Rn.33598