Rat Mucin-4(MUC4) ELISA kit

产品详情

产品描述：

大鼠粘蛋白-4(MUC4)酶联免疫试剂盒（CSB-EL015227RA）为双抗夹心法ELISA试剂盒，定量检测血清、血浆、组织匀浆样本中的MUC4含量。MUC4是一种跨膜黏蛋白，在多种恶性肿瘤中高表达。其背景上，与肿瘤的发生、发展及转移密切相关。研究机制方面，它能参与细胞信号传导，调节细胞黏附、增殖和凋亡等过程，还可影响肿瘤微环境，成为肿瘤治疗有潜力的靶点。试剂盒检测范围为0.78 ng/mL-50 ng/mL，适用于科研领域中对呼吸道、消化道等黏膜相关疾病模型、肿瘤微环境研究或药物干预实验中MUC4蛋白动态变化的定量分析，为探索黏膜屏障功能调节机制及生物标志物研究提供可靠工具。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
别名：

Muc4; Smc; Mucin-4; MUC-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Pre-sialomucin complex; pSMC; Sialomucin complex; Testis mucin
缩写：

MUC4
Uniprot No.：

Q63661
种属：

Rattus norvegicus (Rat)
样本类型：

serum, plasma, tissue homogenates
检测范围：

0.78 ng/mL-50 ng/mL
灵敏度：

0.195 ng/mL
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Signal Transduction
测定原理：

quantitative
测定方法：

Sandwich
数据处理：

ELISA操作视频及标曲绘制软件下载
货期：

3-5 working days

功能：

Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation.
亚细胞定位：

[Mucin-4 beta chain]: Cell membrane; Multi-pass membrane protein.; [Mucin-4 alpha chain]: Secreted.
组织特异性：

Expression is developmentally regulated in the mammary gland, dramatically increases in the lactating gland compared with the virgin mammary gland, while decreasing again during mammary gland involution. Expressed in 13762 ascites cells. Overexpressed in