Rat Macrophage Colony-Stimulating Factor,M-CSF ELISA kit

文献引用 (5)

中文名称：

大鼠巨噬细胞集落刺激因子(M-CSF)酶联免疫试剂盒
货号：

CSB-E07424r
规格：

96T/48T
价格：

￥3900/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

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CUSABIO大鼠巨噬细胞集落刺激因子（M-CSF）酶联免疫检测试剂盒（货号：CSB-E07424r），采用双抗体夹心法定量检测血清、血浆、细胞培养上清及组织匀浆样本中的M-CSF浓度，检测灵敏度范围为0.156 ng/ml至10 ng/ml。M-CSF是调控巨噬细胞增殖、分化及存活的关键细胞因子，广泛参与免疫调节、组织修复及炎症反应等生物学过程，其水平变化与多种疾病模型的研究密切相关。本试剂盒通过预包被特异性抗体捕获样本中的目标蛋白，结合酶标二抗进行信号放大，最终显色强度与M-CSF浓度呈正相关，具有高特异性和重复性。适用于科研领域中评估大鼠感染模型、自身免疫性疾病研究或药物干预实验中M-CSF的动态表达，亦可用于体外培养巨噬细胞功能研究时的细胞因子分泌检测。实验操作兼容多种生物样本类型，配备标准化校准品与缓冲体系，可满足基础研究、病理机制探索及生物标志物分析等多元化需求。
别名：

Csf1 ELISA kit; CsfmMacrophage colony-stimulating factor 1 ELISA kit; CSF-1 ELISA kit; MCSF) [Cleaved into: Processed macrophage colony-stimulating factor 1] ELISA kit
缩写：

CSF1
Uniprot No.：

Q8JZQ0
种属：

Rattus norvegicus (Rat)
样本类型：

serum, plasma, cell culture supernates, tissue homogenates
检测范围：

0.156 ng/ml - 10 ng/ml
灵敏度：

0.039 ng/ml
反应时间：

1-5h
样本体积：

50-100ul
检测波长：

450 nm
研究领域：

Cardiovascular
测定原理：

quantitative
测定方法：

Sandwich
精密度：
线性度：
回收率：
标准曲线：
数据处理：

ELISA操作视频及标曲绘制软件下载
货期：

3-5 working days

引用文献

Mesenchymal Stem Cells and Myeloid-Derived Suppressor Cells Interplay in Adjuvant-Induced Arthritis Rat Model FAM Abo-Aziza,International immunopharmacology,2023
Reversing Postcardiopulmonary Bypass Associated Cognitive Dysfunction Using k-Opioid Receptor Agonists to Regulate Microglial Polarization via the NLRP3/Caspase-1 Pathway Pei Song,Journal of Healthcare Engineering,2021
EXPANSION, ACTIVATION AND FUNCTION PROMOTION OF MYELOID-DERIVED SUPPRESSOR CELLS IN ADJUVANT-INDUCED ARTHRITIS Abd-Elhalem S S, et al,European Journal of Biomedical,2019
Functionalized cerium oxide nanoparticles mitigate the oxidative stress and pro-inflammatory activity associated to the portal vein endothelium of cirrhotic rats Ribera J, et al,Plos One,2019
Elderly-onset hereditary pulmonary alveolar proteinosis and its cytokine profile Masayuki Ito.et al,BMC Pulmonary Medicine,2017

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功能：

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
相关疾病：

A defect in Csf1 is the cause of the toothless phenotype (tl). Toothless rats display osteoclastopenia, severe osteopetrosis, and dystrophic growth plates.
亚细胞定位：

Cell membrane; Single-pass type I membrane protein.; [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.
数据库链接：

STRING: 10116.ENSRNOP00000025221

UniGene: Rn.83632

Rat Macrophage Colony-Stimulating Factor,M-CSF ELISA kit

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