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中文名称：大鼠嗜酸粒细胞趋化蛋白Eotaxin 1(Eotaxin 1/CCL11)酶联免疫试剂盒
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货号：CSB-E07319r
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规格：96T/48T
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价格：￥3200/￥2500
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其他：
产品详情
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产品描述：CUSABIO双抗体夹心法ELISA试剂盒，专用于定量检测大鼠血清、血浆及组织匀浆样本中的嗜酸粒细胞趋化蛋白Eotaxin 1（CCL11）。Eotaxin 1作为CC趋化因子家族成员，通过结合CCR3受体参与嗜酸性粒细胞的定向迁移，在过敏性炎症、哮喘及组织纤维化等病理过程中发挥重要作用。试剂盒采用预包被特异性抗体的96孔板，通过标准品梯度（15.6-1000 pg/ml）建立定量曲线，利用HRP标记的检测抗体与TMB显色系统实现目标蛋白的精准测定，最低检测限达15.6 pg/ml，适用于呼吸道疾病模型研究、炎症机制探索及药物干预效果评估等科研场景。实验全程约需4小时，配套提供标准品、检测抗体及终止液等完整组分，支持血清/血浆样本直接检测，组织样本需经适当匀浆处理，建议通过预实验优化样本稀释比例以确保检测值位于线性范围内。
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别名：Ccl11 ELISA Kit; Scya11Eotaxin ELISA Kit; C-C motif chemokine 11 ELISA Kit; Eosinophil chemotactic protein ELISA Kit; Small-inducible cytokine A11 ELISA Kit
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缩写：
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Uniprot No.：
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种属：Rattus norvegicus (Rat)
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样本类型：serum, plasma, tissue homogenates
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检测范围：15.6 pg/ml -1000 pg/ml
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灵敏度：3.9 pg/ml
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反应时间：1-5h
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样本体积：50-100ul
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检测波长：450 nm
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研究领域：Immunology
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测定原理：quantitative
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测定方法：Sandwich
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精密度：
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线性度：
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回收率：
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标准曲线：
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数据处理：
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货期：3-5 working days
引用文献
- Protein tyrosine phosphatase 11 acts through RhoA/ROCK to regulate eosinophil accumulation in the allergic airway Xu C, et al,Faseb Journal,2019
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靶点详情
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功能：In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils. Binds to CCR3.
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基因功能参考文献：
- our data suggest that the CCL11-CCR3 interaction mainly activates PI3K/Akt signal transduction pathway in HUVECs. PMID: 28279120
- Iddm30 controls pancreatic expression of Ccl11 (Eotaxin) and the Th1/Th2 balance within the insulitic lesions. PMID: 24646746
- Tripterine can inhibit expression of Eotaxin by restraining the activation of NF-kappaB in the nasal musoca of rats with allergic rhinitis. PMID: 23272499
- expression of Ccl11 associates with immune response modulation in experimental autoimmune encephalomyelitis PMID: 22815714
- Intervention of PRMT1 activity can abrogate IL-4-dependent eotaxin-1 production to influence the pulmonary inflammation with eosinophil infiltration. PMID: 22387551
- The expression of Eotaxin in nasal lavage fluid and nasal mucosa increased after treatment of allergic rhinitis with histamine. PMID: 20359111
- The expression of Eotaxin in nasal mucosa increased, and the expression of CCR3 in bone marrow increased in the model of allergic rhinitis. PMID: 16722399
- Suppression of eotaxin by CpG DNA reduced the symptoms of experimental allergic rhinitis. PMID: 16838745
- Targeting CCL11 with monoclonal antibodies possibly results in decreased myocardial fibrosis and improves contractile function after heart transplantation ub rats. PMID: 20832583
- Galectin-3 inhibited expression of eotaxin and IL5, potentially suppressing eosinophilic inflammation in asthma. PMID: 17074272
- Eotaxin is upregulated in the pancreatic lymph nodes and may play a role in early disease pathogenesis of type 1 diabetes mellitus in the BioBreeding rat model. PMID: 15557196
- In a model of ongoing acute heart transplant rejection in the rat, we found eotaxin mRNA expression within infiltrating macrophages, but not in mast cells PMID: 19631640
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亚细胞定位：Secreted.
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蛋白家族：Intercrine beta (chemokine CC) family
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数据库链接：
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