Rat Apolipoprotein A5(apo-A5)ELISA Kit
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中文名称:大鼠载脂蛋白A5(apo-A5)酶联免疫试剂盒
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货号:CSB-E16334r
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规格:96T/48T
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价格:¥3600/¥2500
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其他:
产品详情
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产品描述:大鼠载脂蛋白A5(apo-A5)酶联免疫试剂盒(CSB-E16334r)为竞争法ELISA试剂盒,定量检测样本中的APOA5含量。APOA5是一个重要靶点。它在脂质代谢中起关键作用,其表达水平与甘油三酯浓度密切相关。研究机制方面,主要围绕其调控脂蛋白代谢过程展开,通过影响载脂蛋白功能等方式,在心血管疾病等相关疾病研究中备受关注。本产品适用于科研领域研究apo - A5在脂质代谢调控中的作用机制;本产品可为研究脂代谢紊乱动物模型、药物干预效果评价或基因表达调控实验提供可靠的检测工具,广泛应用于心血管疾病、代谢综合征等领域的机制探索。本品仅用于科研,不用于临床诊断,产品具体参数及操作步骤详见产品说明书。
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别名:Apoa5 ELISA kit; Rap3Apolipoprotein A-V ELISA kit; Apo-AV ELISA kit; ApoA-V ELISA kit; Apolipoprotein A5 ELISA kit; Regeneration-associated protein 3 ELISA kit
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缩写:
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Uniprot No.:
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种属:Rattus norvegicus (Rat)
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样本类型:
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检测范围:
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灵敏度:
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反应时间:1-5h
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样本体积:50-100ul
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检测波长:450 nm
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研究领域:Cancer
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测定原理:quantitative
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测定方法:Competitive
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精密度:
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线性度:
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回收率:
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标准曲线:
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数据处理:
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货期:3-5 working days
相关产品
靶点详情
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最新研究进展:APOA5是一种与三酰甘油代谢和心血管疾病风险密切相关的蛋白。最新的研究表明,APOA5可能还具有调节肝细胞脂代谢和炎症反应的作用。一项发表在Journal of Lipid Research上的研究发现,APOA5通过调节脂代谢酶基因的表达,影响肝脏脂质代谢和三酰甘油的水平。此外,一些研究还发现,APOA5与胰岛素抵抗、非酒精性脂肪肝等疾病有关。
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功能:Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin.
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基因功能参考文献:
- Our data support the hypothesis that apoA5 promotes hepatic TG storage and therefore contributes to the pathogenesis of non-alcoholic fatty liver disease PMID: 25938357
- Demonstrate that apoA-V is secreted into bile, introducing a potential route of delivery of hepatic apoA-V to the gut lumen. PMID: 26505974
- The increase in apolipoprotein A mRNA induced by rosiglitazone is not directly mediated by peroxisome proliferator-activated receptor gamma.[apolipoprotein av] PMID: 16570166
- apoA-V inefficiently traffics within the secretory pathway, that its intracellular itinerary can be regulated by changes in cellular TG accumulation, and that apoA-V synthesis can modulate VLDL TG mobilization and secretion. PMID: 21115968
- decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity PMID: 20047745
- ApoA-V ability to enhance insulin secretion in beta-cells and provide evidence of an internalization pathway involving the midkine as partner. PMID: 19910685
- the hypotriglyceridemic gene APOA5 is regulated by thyroid hormone PMID: 15941710
- The absence of significant changes in Apoa5 gene expression during chronic fructose-induced triglyceride elevation excludes its major role in mechanisms compensating severe hypertriglyceridemia PMID: 16238453
- data suggest that the C terminus of apoA-V is essential for lipid droplet association in transfected hepatoma cells and lipoprotein association in conditioned medium while the signal peptide is required for extracellular trafficking of this protein. PMID: 18450648
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亚细胞定位:Secreted. Early endosome. Late endosome. Golgi apparatus, trans-Golgi network.
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蛋白家族:Apolipoprotein A1/A4/E family
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组织特异性:Liver.
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数据库链接:
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