Mouse neurotensin (NTS) ELISA kit

1. Study reveals multiple populations of neurotensin neurons that provide direct afferents to the ventral tegmental area and which may regulate specific aspects of motivated behavior. PMID: 29478718
2. The weight loss behaviors are mediated by distinct signaling pathways: Nts action via NtsR1 is essential for the anorectic effect of the lateral hypothalamic Nts circuit, but not for regulation of locomotor or drinking behavior. PMID: 29241540
3. Nts-leptin receptor neurons are important neuronal hubs within the lateral hypothalamic area for hormone-mediated control of ingestive and locomotor behaviors. PMID: 28323938
4. findings directly link NT with increased fat absorption and obesity and suggest that NT may provide a prognostic marker of future obesity and a potential target for prevention and treatment PMID: 27193687
5. Data (including data from studies in transgenic mice) suggest Nts, glucagon-like peptide I, and peptide YY are closely co-expressed/co-secreted within enteroendocrine cells in ileum mucosa; however, Nts is stored in distinct/separate secretory granules. PMID: 26469136
6. The roles of neurotensin and its receptor NTR-1 on sperm capacitation and acrosome reaction in mice are reported. PMID: 25031361
7. These observations suggest the importance of neurotensin in maintaining activity of orexin neurons. PMID: 23620827
8. a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK, secretin, GIP, GLP-1, PYY, and neurotensin PMID: 23064014
9. Neurotensin knock-out mice do not differ from their wild-type or heterozygous littermates in either baseline or acute cocaine-stimulated locomotor activity. PMID: 21720755
10. Neurotensin increases EGF expression in skin dendritic cells. PMID: 21767580
11. NT acutely regulates D2 autoreceptor function and DA neuron excitability through PKC-mediated phosphorylation of the D2R, leading to heterologous receptor desensitization. PMID: 21233215
12. although neurotensin neurons in the anteroventral periventricular nucleus are targets for regulation by E(2), neurotensin does not appear to play a direct role in generating the GnRH/LH surge in the mouse PMID: 19861584
13. neurotensin has a role in chronic mitogen-activated protein kinase activation and cancer progression PMID: 14699144
14. Data show that although brain neuromedin N mRNA distribution largely overlaps in mice and rats, species differences exist in specific brain areas, and the distribution in mice resembles that of primates more than that of rats. PMID: 15193419
15. NT and NTR1 are part of network activated after mucosal injuries, and NT stimulates epithelial restitution, at least in part, through a COX-2 dependent pathway. PMID: 15764810
16. Neurotensin may have a direct role in the neuroendocrine control of feeding and energy homeostasis. PMID: 16221860
17. co-localization of peptides and enzyme in GHRH-eGFP neurons displays a sexual dimorphism at 3-month of age for NT, and at 8-month for tyrosine hydroxylase, while the total number of GHRH-eGFP neurons does not exhibit gender difference at either age. PMID: 17137749
18. [(99m)Tc]Demotensin 6 shows a favourable preclinical profile and further testing in patients is warranted to monitor its eventual applicability as a radiotracer in the diagnostic imaging of NTS1-R-positive tumours. PMID: 17594090
19. These results clearly indicate for the first time that NT is able to protect endocrine beta cells from external cytotoxic agents, a role well correlated with its release in the circulation after a meal. PMID: 18456542
20. NT-mediated IL-6 expression is nuclear factor-kappaB and PKCdelta dependent PMID: 19443690

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KEGG: mmu:67405

STRING: 10090.ENSMUSP00000020040

UniGene: Mm.64201