Mouse guanylate cyclase activator 2B (uroguanylin) (GUCA2B) ELISA kit
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中文名称:小鼠鸟苷酸环化酶激活剂2B(尿鸟苷素)(GUCA2B)酶联免疫试剂盒
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货号:CSB-EL010048MO
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规格:96T/48T
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价格:¥3600/¥2500
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其他:
产品详情
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产品描述:小鼠鸟苷酸环化酶激活剂2B(尿鸟苷素)(GUCA2B)酶联免疫试剂盒(CSB-EL010048MO)为双抗夹心法ELISA试剂盒,定量检测血清、血浆、组织匀浆样本中的GUCA2B含量。GUCA2B,又称尿鸟苷酸,是一种候选的肠钠尿激素,负责调节肠道与肾脏之间的钠和水平衡。研究显示,GUCA2B基因敲除小鼠血压升高,提示其可能与原发性高血压相关。其研究机制涉及激活鸟苷酸环化酶活性,参与cGMP介导的信号传导。试剂盒检测范围为62.5 ng/ml-4000ng/ml,灵敏度为15.6 ng/ml。可应用于胃肠动力研究、肾脏生理学实验、代谢性疾病模型构建等科研领域,为探究GUCA2B在消化系统、泌尿系统相关分子机制提供可靠工具。本品仅用于科研,不用于临床诊断,产品具体参数及操作步骤详见产品说明书。
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别名:Guca2b ELISA Kit; Guanylate cyclase activator 2B [Cleaved into: Uroguanylin ELISA Kit; UGN)] ELISA Kit
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缩写:GUCA2B
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Uniprot No.:
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种属:Mus musculus (Mouse)
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样本类型:serum, plasma, tissue homogenates
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检测范围:62.5 ng/ml-4000ng/ml
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灵敏度:15.6 ng/ml
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反应时间:1-5h
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样本体积:50-100ul
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检测波长:450 nm
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研究领域:Signal Transduction
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测定原理:quantitative
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测定方法:Sandwich
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数据处理:
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货期:3-5 working days
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靶点详情
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最新研究进展:GUCA2B(鸟苷酸酰化酶2B)是一种胃肠道分泌物,主要由肠道细胞产生,可通过粪便等渠道排出体外。近年来的研究发现,GUCA2B具有重要的生物学功能,可通过多种途径参与胃肠道生理过程的调节,如促进肠道蠕动、抗炎作用、维护肠道屏障功能等。此外,GUCA2B还可能与胃肠道癌症、肠易激综合征等疾病的发生发展相关。
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功能:Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
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基因功能参考文献:
- In obese mice UGN expression was decreased, whereas leptin treatment up-regulated UGN levels in duodenum in these genetically modified mice compared to WT. PMID: 25743370
- UGN exerts its inhibitory activity on the prendrin gene promoter likely via heat shock factor 1 action at a defined heat shock element site. PMID: 22129966
- findings establish a role for uroguanylin in an enteric-renal communication axis as well as a fundamental principle of this axis in the maintenance of salt homeostasis in vivo PMID: 14561709
- act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes. PMID: 14675035
- Role for uroguanylin in fluid homeostasis and as an integral component of a signaling mechanism that mediates changes in Na excretion in response to an enteral salt loading. PMID: 16819406
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亚细胞定位:Secreted.
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蛋白家族:Guanylin family
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组织特异性:Localized predominantly in intestinal villi and the corticomedullary junction of the kidney.
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数据库链接:
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