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Mouse guanylate cyclase activator 2B (uroguanylin) (GUCA2B) ELISA kit

  • 中文名称:
    小鼠鸟苷酸环化酶激活剂2B(尿鸟苷素)(GUCA2B)酶联免疫试剂盒
  • 货号:
    CSB-EL010048MO
  • 规格:
    96T/48T
  • 价格:
    ¥3600/¥2500
  • 其他:

产品详情

  • 产品描述:
    小鼠鸟苷酸环化酶激活剂2B(尿鸟苷素)(GUCA2B)酶联免疫试剂盒(CSB-EL010048MO)为双抗夹心法ELISA试剂盒,定量检测血清、血浆、组织匀浆样本中的GUCA2B含量。GUCA2B,又称尿鸟苷酸,是一种候选的肠钠尿激素,负责调节肠道与肾脏之间的钠和水平衡。研究显示,GUCA2B基因敲除小鼠血压升高,提示其可能与原发性高血压相关。其研究机制涉及激活鸟苷酸环化酶活性,参与cGMP介导的信号传导。试剂盒检测范围为62.5 ng/ml-4000ng/ml,灵敏度为15.6 ng/ml。可应用于胃肠动力研究、肾脏生理学实验、代谢性疾病模型构建等科研领域,为探究GUCA2B在消化系统、泌尿系统相关分子机制提供可靠工具。本品仅用于科研,不用于临床诊断,产品具体参数及操作步骤详见产品说明书。
  • 别名:
    Guca2b ELISA Kit; Guanylate cyclase activator 2B [Cleaved into: Uroguanylin ELISA Kit; UGN)] ELISA Kit
  • 缩写:
    GUCA2B
  • Uniprot No.:
  • 种属:
    Mus musculus (Mouse)
  • 样本类型:
    serum, plasma, tissue homogenates
  • 检测范围:
    62.5 ng/ml-4000ng/ml
  • 灵敏度:
    15.6 ng/ml
  • 反应时间:
    1-5h
  • 样本体积:
    50-100ul
  • 检测波长:
    450 nm
  • 研究领域:
    Signal Transduction
  • 测定原理:
    quantitative
  • 测定方法:
    Sandwich
  • 数据处理:
  • 货期:
    3-5 working days

产品评价

靶点详情

  • 最新研究进展:
    GUCA2B(鸟苷酸酰化酶2B)是一种胃肠道分泌物,主要由肠道细胞产生,可通过粪便等渠道排出体外。近年来的研究发现,GUCA2B具有重要的生物学功能,可通过多种途径参与胃肠道生理过程的调节,如促进肠道蠕动、抗炎作用、维护肠道屏障功能等。此外,GUCA2B还可能与胃肠道癌症、肠易激综合征等疾病的发生发展相关。
  • 功能:
    Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
  • 基因功能参考文献:
    1. In obese mice UGN expression was decreased, whereas leptin treatment up-regulated UGN levels in duodenum in these genetically modified mice compared to WT. PMID: 25743370
    2. UGN exerts its inhibitory activity on the prendrin gene promoter likely via heat shock factor 1 action at a defined heat shock element site. PMID: 22129966
    3. findings establish a role for uroguanylin in an enteric-renal communication axis as well as a fundamental principle of this axis in the maintenance of salt homeostasis in vivo PMID: 14561709
    4. act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes. PMID: 14675035
    5. Role for uroguanylin in fluid homeostasis and as an integral component of a signaling mechanism that mediates changes in Na excretion in response to an enteral salt loading. PMID: 16819406

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  • 亚细胞定位:
    Secreted.
  • 蛋白家族:
    Guanylin family
  • 组织特异性:
    Localized predominantly in intestinal villi and the corticomedullary junction of the kidney.
  • 数据库链接:

    KEGG: mmu:14916

    STRING: 10090.ENSMUSP00000043203

    UniGene: Mm.278