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中文名称：小鼠趋化因子配体17(CXCL17)酶联免疫试剂盒
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货号：CSB-EL006246MO
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规格：96T/48T
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价格：￥3600/￥2500
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其他：
产品详情
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产品描述：CUSABIO小鼠趋化因子配体17（CXCL17）特异性检测试剂盒，采用双抗体夹心酶联免疫吸附法（ELISA）实现定量分析，适用于血清、血浆及组织匀浆样本中CXCL17蛋白含量的精准测定。CXCL17作为新型趋化因子家族成员，在黏膜免疫调节及炎症反应中发挥重要作用，尤其在呼吸道和消化道相关疾病模型中具有研究价值。该试剂盒检测灵敏度高，线性范围覆盖37.5至2400 pg/mL，可有效检测样本中不同浓度水平的CXCL17蛋白。实验操作流程包含预包被特异性捕获抗体的酶标板、生物素标记检测抗体及链霉亲和素-HRP系统，通过标准品浓度梯度建立标准曲线实现目标蛋白定量。科研人员可将其应用于炎症性疾病机制研究、免疫微环境分析或药物干预模型中趋化因子动态变化的评估，为探索CXCL17在先天免疫调控、组织修复及病理状态下的功能提供可靠工具。本试剂盒配套提供标准品、检测抗体及全套实验缓冲液，需自备酶标仪和洗板设备，实验全程需在生物安全二级实验室规范操作。
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别名：Cxcl17 ELISA kit; Vcc1C-X-C motif chemokine 17 ELISA kit; 6-Cys CXCL17 ELISA kit; 13.6 kDa protein ELISA kit; VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17] ELISA kit
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缩写：CXCL17
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Uniprot No.：
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种属：Mus musculus (Mouse)
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样本类型：serum, plasma, tissue homogenates
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检测范围：37.5 pg/mL-2400 pg/mL
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灵敏度：9.375 pg/mL
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反应时间：1-5h
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样本体积：50-100ul
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检测波长：450 nm
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研究领域：Immunology
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测定原理：quantitative
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测定方法：Sandwich
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数据处理：
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货期：3-5 working days
引用文献
- CXCL17 Attenuates Diesel Exhaust Emissions Exposure-Induced Lung Damage by Regulating Macrophage Function Y Yin,Toxics,2023
- CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB Hsu YL, et al,Breast Cancer Research,2019
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靶点详情
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功能：Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions.
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基因功能参考文献：
- CXCL17 attenuates Imiquimod -induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells , which may be important for regulating excessive inflammation in psoriasis skin. PMID: 28389593
- CXCL17 is a novel macrophage chemoattractant that operates in mucosal tissues as a major regulator of inflammatory responses. PMID: 24973458
- These results suggest that aberrant expression of CXCL17 in tumor cells recruits immature myeloid-derived cells and promotes tumor progression through angiogenesis. PMID: 22952881
- VCC-1 plays a role in angiogenesis and possibly in the development of tumors in some tissue types[VCC-1] PMID: 16989774
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亚细胞定位：Secreted.
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蛋白家族：Intercrine alpha (chemokine CxC) family
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组织特异性：Detected in lung, trachea, lung, tongue thyroid, submaxillary gland, epididymis, and uterus tissues and at a lower level in ovary, prostate and in intestinal tissues.
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数据库链接：
KEGG: mmu:232983
UniGene: Mm.10545
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