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Mouse chemokine (C-C motif) ligand 1 ELISA Kit

  • 中文名称:
    小鼠趋化因子配体1酶联免疫试剂盒
  • 货号:
    CSB-E14298m
  • 规格:
    96T/48T
  • 价格:
    ¥3600/¥2500
  • 其他:

产品详情

  • 产品描述:
    CUSABIO小鼠趋化因子配体1(CXCL1)酶联免疫检测试剂盒(货号:CSB-E14298m),采用双抗体夹心法定量检测血清、血浆或组织匀浆样本中CXCL1的蛋白表达水平。CXCL1属于CXC趋化因子家族成员,在炎症反应、中性粒细胞趋化及肿瘤微环境调控中发挥重要作用,是研究感染性疾病、自身免疫性疾病及肿瘤免疫机制的重要靶点。试剂盒检测灵敏度为3.9 pg/ml,线性检测范围为7.8-500 pg/ml,适用于检测低丰度样本,操作全程仅需3.5小时,推荐使用100 μL样本量进行检测。试剂盒组分包含预包被抗体、检测抗体、标准品及显色系统,保存于2-8℃条件下有效期达6个月,使用前需平衡至室温并避免反复冻融。该产品可应用于基础科研中评估炎症模型小鼠的CXCL1动态表达、探索肿瘤微环境中趋化因子的调控机制,或用于药物干预实验中的生物标志物检测,为炎症性疾病和肿瘤免疫研究提供可靠的实验工具。
  • 别名:
    Ccl1 ELISA kit; Scya1 ELISA kit; Tca3C-C motif chemokine 1 ELISA kit; P500 ELISA kit; SIS-epsilon ELISA kit; Small-inducible cytokine A1 ELISA kit; T-cell activation protein 3 ELISA kit; TCA-3 ELISA kit; TCA3 ELISA kit
  • 缩写:
  • Uniprot No.:
  • 种属:
    Mus musculus (Mouse)
  • 样本类型:
    serum, plasma, tissue homogenates
  • 检测范围:
    7.8 pg/ml -500 pg/ml
  • 灵敏度:
    1.95 pg/ml
  • 反应时间:
    1-5h
  • 样本体积:
    50-100ul
  • 检测波长:
    450 nm
  • 研究领域:
    Immunology
  • 测定原理:
    quantitative
  • 测定方法:
    Sandwich
  • 数据处理:
  • 货期:
    3-5 working days

产品评价

靶点详情

  • 功能:
    Cytokine that is chemotactic for neutrophils.
  • 基因功能参考文献:
    1. Findings provide evidence that CCL1 possibly contributes to 5-fluorouracil/paclitaxel chemoresistance in CT26 colorectal cell line via TGF-beta and nuclear factor-kappa B signaling pathways. PMID: 28934847
    2. Sca-1(+) progenitor cells found to exhibit increased migration was associated with elevated levels of chemokines, CCL2 (chemokine (C-C motif) ligand 2) and CXCL1 (chemokine (C-X-C motif) ligand 1), and their corresponding receptors. PMID: 27300479
    3. Study reports showing that I. ricinus saliva can increase the production of three chemokines, CCL1, CCL2 and CXCL2. This upregulation reflects Th2 polarization of the host immunity due to the effect of tick saliva and in the case of CCL2 probably facilitates tick engorgement in the late, rapid feeding phase. PMID: 25545116
    4. Our data indicate that estradiol is important in regulating the effects of keratinocyte growth factor on mouse uterine epithelial cell secretion of CCL20 and CXCL1. PMID: 24807244
    5. CCL-1 is one of the key molecules in pathogenesis in neuropathic pain. PMID: 23788036
    6. These data identify a novel function for CCL1-CCR8 in metastasis and lymph node LECs as a critical checkpoint for the entry of metastases into the lymph nodes. PMID: 23878309
    7. Egr2-deficient mast cells were incapable of directing CD4(+) T cell migration via the CCL1-CCR8 axis. PMID: 23536637
    8. results indicate that CCL1 released from M2bM is essentially required for the maintenance of their properties PMID: 22730547
    9. C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
    10. These findings reveal the importance of CXCL1 produced by hematopoietic and resident cells in regulating pulmonary host defense against a bacterial pathogen PMID: 20937845
    11. neutralization of CCL1 can be used as an adjuvant to antitumor immunotherapy, as a means of reversing the immunosuppressive function of Tregs without compromising T cell effector function. PMID: 20483762
    12. increased responsivenss of murine eosiophils to TCA-3 is mediated by CCR8 receptor in mice PMID: 12050188
    13. After stimulation via high-affinity FcepsilonRI, the transcriptional levels of I-309 (CCL1), MIP-1alpha (CCL3) and MIP-1beta (CCL4) were found among the 10 most increased human and mouse transcripts from approximately 12 000 genes PMID: 12393595
    14. CCL1 is involved in the recruitment of eosinophils in several models of allergic inflammation, but it is not important for the recruitment of Th2 cells to the lung. PMID: 12707363
    15. Benzo(a)pyrene and an aryl hydrocarbon receptor agonist enhance activitity of te Ccl1 promoter. PMID: 16679317
    16. These data demonstrate that the chemokine TCA3/CCL1 is important to the pathogenesis of ischemic injury of experimental partial liver grafts. PMID: 17164723
    17. Mast cell-derived CCL1- and CCR8-expressing CD4-positive effector T lymphocytes play an essential role in orchestrating lung mucosal inflammatory responses. PMID: 17641040
    18. CCR8/CCL1 interaction may play a role in type 1 diabetes through macrophage recruitment and activation PMID: 17947648
    19. lovastatin-induced increase in regulatory T cells in inflamed skin was dependent on expression of CCL1, that is locally up-regulated by statin administration. PMID: 18714025
    20. In a novel mechanism, IL-12 augments naive CD8 T cell activation by facilitating CCL1 production by dendritic cells, thus promoting more stable cognate interactions during priming. PMID: 19050277

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  • 蛋白家族:
    Intercrine beta (chemokine CC) family
  • 数据库链接:

    KEGG: mmu:20290

    STRING: 10090.ENSMUSP00000103824

    UniGene: Mm.1283