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中文名称:小鼠β淀粉样蛋白1-42(Aβ1-42)酶联免疫试剂盒
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货号:CSB-E10787m
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规格:96T/48T
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价格:¥3800/¥2500
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其他:
产品详情
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产品描述:CUSABIO定量检测小鼠血清、血浆及组织匀浆中β淀粉样蛋白1-42(Aβ1-42)的酶联免疫试剂盒,基于双抗体夹心原理开发,适用于神经退行性疾病相关科研领域。Aβ1-42作为阿尔茨海默病的关键病理标志物,其异常沉积与神经元损伤密切相关,该试剂盒通过高灵敏度抗体对实现15.6-1000 pg/mL的宽范围检测,能够精准量化样本中Aβ1-42的动态变化。实验体系包含预包被捕获抗体和生物素标记检测抗体,通过链霉亲和素-HRP显色系统实现目标蛋白定量分析,操作流程标准化且重复性良好。其多样本兼容性支持研究者同时分析循环系统(血清/血浆)与脑组织等局部病灶中的蛋白表达差异,适用于阿尔茨海默病小鼠模型构建、Aβ病理机制研究、药物干预效果评估等实验场景,为神经科学领域提供可靠的检测工具。本产品严格验证批次稳定性,实验全程无需特殊设备,配套标准品及缓冲液确保实验便捷性,满足体外科研检测需求。
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别名:Amyloid beta 42(ABeta 42),amyloid beta peptide 1-42,Aβ1-42,amyloid βpeptide 1-42
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缩写:Aβ1-42
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种属:Mus musculus (Mouse)
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样本类型:serum, plasma, tissue homogenates
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检测范围:15.6 pg/mL-1000 pg/mL
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灵敏度:3.9 pg/mL
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反应时间:1-5h
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样本体积:50-100ul
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检测波长:450 nm
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研究领域:Neuroscience
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测定原理:quantitative
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测定方法:Sandwich
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
线性度:
To assess the linearity of the assay, samples were spiked with high concentrations of mouse Aβ1-42 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 92 Range % 88-99 1:2 Average % 95 Range % 85-105 1:4 Average % 96 Range % 90-105 1:8 Average % 93 Range % 86-100 -
回收率:
The recovery of mouse Aβ1-42 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 95 90-100 EDTA plasma (n=4) 93 85-96 -
标准曲线:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. pg/ml OD1 OD2 Average Corrected 1000 2.490 2.451 2.471 2.337 500 2.049 1.985 2.017 1.883 250 1.357 1.385 1.371 1.237 125 0.866 0.837 0.852 0.718 62.5 0.517 0.524 0.521 0.387 31.2 0.347 0.355 0.351 0.217 15.6 0.244 0.228 0.236 0.102 0 0.135 0.132 0.134 -
数据处理:
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货期:3-5 working days
引用文献
- A Novel Missense Variant in SORBS2 Is Causative With Familial Alzheimer's Disease Q Wang, S Wang, S Cao, Q Wang, Y Wei,CNS Neuroscience & Therapeutics,2025
- Ultrasound Stimulation Modulates Microglia M1/M2 Polarization and Affects Hippocampal Proteomic Changes in a Mouse Model of Alzheimer's Disease X Lu, W Sun, L Leng, Y Yang, S Gong,Immunity, Inflammation and Disease,2024
- Inhibition of Amyloid-β (Aβ)-Induced Cognitive Impairment and Neuroinflammation in CHI3L1 Knockout Mice through Downregulation of ERK-PTX3 Pathway HJ Ham,International journal of molecular sciences,2024
- Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease Y Guo,In vitro cellular & developmental biology. Animal,2023
- Bioengineered microglia-targeted exosomes facilitate Aβ clearance via enhancing activity of microglial lysosome for promoting cognitive recovery in Alzheimer's disease Y Hao,Biomaterials Advances,2023
- Yuanzhi Powder Facilitated the Aβ Clearance in App/Ps1 Mice: Target to the Drainage of Glymphatic System and Meningeal Lymphatic Vessels J Li,Available at SSRN 4528275,2023
- Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer's disease W Li,BMC medicine,2023
- The multifactorial role of vanillin in amelioration of aluminium chloride and D-galactose induced Alzheimer's disease in mice A Anand,European journal of pharmacology,2023
- TNIP2 Inhibits Amyloidogenesis by Regulating the 3'UTR of BACE1 L Wang,Neuroscience letters,2023
- TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: an in vitro study L Chen,Neuroscience letters,2023
- Protective Effect of Biobran/MGN-3 against Sporadic Alzheimer's Disease Mouse Model: Possible Role of Oxidative Stress and Apoptotic Pathways MH Ghoneu,Oxidative Medicine and Cellular Longevity,2021
- Suan-Zao-Ren Decoction ameliorates synaptic plasticity through inhibition of the Aβ deposition and JAK2/STAT3 signaling pathway in AD model of APP/PS1 transgenic mice Qing-Hua Lon,BMC Chinese Medicine,2021
- Astaxanthin Improved the Cognitive Deficits in APP/PS1 Transgenic Mice Via Selective Activation of mTOR C Huang,Journal of Neuroimmune Pharmacology,2020
- Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: Involvements of AMPK/SIRT1 pathway and amyloid-tau-neuroinflammation axis R Hao,Food and Chemical Toxicology,2020
- Long-term consumption of alcohol exacerbates neural lesions by destroying the functional integrity of the blood-brain barrier Wei J, et al,Drug and Chemical Toxicology,2019
- Nanoformulated ellagic acid ameliorates pentylenetetrazol-induced experimental epileptic seizures by modulating oxidative stress, inflammatory cytokines and apoptosis in the brains of male mice El-Missiry M A, et al,Metabolic Brain Disease,2019
- Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice Ham H J, et al,Translational Neurodegeneration,2019
- Albiflorin ameliorates memory deficits in APP/PS1 transgenic mice via ameliorating mitochondrial dysfunction Xu YJ,Brain Research,2019
- PROTEASOME INHIBITORS Kim, Kyung Bo,/,2019
- MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation Zhu BL, et al,Brain,2019
- K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression Ji Yeon Choi, .et al,Journal of Neuroinflammation,2018
- Knockdown of BACE1 Wenting Zhang.et al,EXP THER MED,2018
- Stereoisomers of Schisandrin B Are Potent ATP Competitive GSK-3β Inhibitors with Neuroprotective Effects against Alzheimer’s Disease: Stereochemistry and Biological Activity Xiao-Long Hu.et al,ACS CHEM NEUROSCI,2018
- Ligustilide ameliorates memory deficiency in APP/PS1 transgenic mice via restoring mitochondrial dysfunction Yi-Jun Xu.et al,/,2018
- The Mechanisms of Bushen-Yizhi Formula as a Therapeutic Agent against Alzheimer\'s Disease Cai H.et al,Sci Rep,2018
- Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice Haobin Cai.et al,learning and memory,2017
- Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer\'s Disease Kuang X.et al,Front Aging Neurosci,2017
- Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid in Counteracting LPS-Induced Neuroinflammation via Modulation of miRNA-155 Sayed AS.et al,Mol Neurobiol,2017
- (E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates LPS-Mediated Memory Impairment by Inhibition of STAT3 Pathway Choi JY.et al,Neuromolecular Med.,2017
- KRICT-9 inhibits neuroinflammation, amyloidogenesis and memory loss in Alzheimer’s disease models Lee DY.et al,Oncotarget.,2017
- Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice Neuroscience.et al,Neuroscience,2017
- The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice Tian F.et al,PLoS One.,2017
- Possible role of metal ionophore against zinc induced cognitive dysfunction in D-galactose senescent mice Kanchan Bharti.et al,Biometals.,2016
- Lactobacillus plantarum CCFM639 can prevent aluminium-induced neural injuries and abnormal behaviour in mice Leilei Yu.et al,Journal of Functional Foods,2017
- Possible role of metal ionophore against zinc induced cognitive dysfunction in D-galactose senescent mice. Bharti K.et al,Biometals.,2016
- Antidiabetic drugs restore abnormal transport of amyloid-ß across the blood-brain barrier and memory impairment in db/db mice Chen F. et al,Neuropharmacology,2015
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相关问答
Hi I would like to ask the following for the item Mouse amyloid beta peptide 1-40 ELISA kits:
1. How may test samples can be performed in 1 kit, is it possible to use the kit for 1 96-well plate
靶点详情
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最新研究进展:Aβ1-42是β淀粉样蛋白(Aβ)家族的一员,它是阿尔茨海默病(AD)病理学的主要成分。最近的研究表明,Aβ1-42的积聚是导致AD的主要因素之一。已经发现许多抗Aβ1-42药物,如免疫疗法和β-淀粉样蛋白药物,这些药物能够清除Aβ1-42,并恢复AD患者的认知能力。此外,一些研究还发现,Aβ1-42可能是癫痫的重要病理因素,这为癫痫治疗提供了新的思路。
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